modification

(redirected from Posttranslational modification)
Also found in: Thesaurus, Medical, Legal, Encyclopedia, Wikipedia.

mod·i·fi·ca·tion

 (mŏd′ə-fĭ-kā′shən)
n.
1. The act or process of modifying or the condition of being modified.
2. A change or a result produced by modifying: new modifications in the car's design.
3. Linguistics
a. A change undergone by a word that is borrowed from another language.
b. A phonological change undergone by a word or morpheme when it is used in a construction, as the change of will to 'll in they'll.

mod′i·fi·ca′tor n.
mod′i·fi·ca′to·ry (-kā′tə-rē), mod′i·fi·ca′tive (-kā′tĭv) adj.

modification

(ˌmɒdɪfɪˈkeɪʃən)
n
1. the act of modifying or the condition of being modified
2. something modified; the result of a modification
3. a small change or adjustment
4. (Grammar) grammar the relation between a modifier and the word or phrase that it modifies
ˈmodifiˌcatory, ˈmodifiˌcative adj

mod•i•fi•ca•tion

(ˌmɒd ə fɪˈkeɪ ʃən)

n.
1. an act or instance of modifying or the state of being modified.
2. a modified form; variety.
3. a change in an organism acquired during its lifetime and not inheritable.
4. limitation or qualification.
5.
a. the use of modifiers in a construction or language.
b. the meaning a modifier has, esp. as it affects the meaning of the word or other form modified, as in limitation.
6. a change in the phonological shape of a morpheme, word, or other form when it functions as an element in a construction, as the change of not to n't in doesn't.
[1495–1505; < Latin]

mod·i·fi·ca·tion

(mŏd′ə-fĭ-kā′shən)
A change in an organism resulting from external influences, and not inheritable.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.modification - the act of making something different (as e.g. the size of a garment)modification - the act of making something different (as e.g. the size of a garment)
laxation, loosening - the act of making something less tight
tightening - the act of making something tighter; "the tightening of economic controls"
change - the action of changing something; "the change of government had no impact on the economy"; "his change on abortion cost him the election"
accommodation - (physiology) the automatic adjustment in focal length of the natural lens of the eye
adaptation - (physiology) the responsive adjustment of a sense organ (as the eye) to varying conditions (as of light)
tune - the adjustment of a radio receiver or other circuit to a required frequency
2.modification - slightly modified copy; not an exact copy; "a modification of last year's model"
copy - a thing made to be similar or identical to another thing; "she made a copy of the designer dress"; "the clone was a copy of its ancestor"
3.modification - the grammatical relation that exists when a word qualifies the meaning of the phrase
grammatical relation - a linguistic relation established by grammar
restrictiveness - a grammatical qualification that makes the meaning more specific (`red hat' has a more specific meaning than `hat')
apposition - a grammatical relation between a word and a noun phrase that follows; "`Rudolph the red-nosed reindeer' is an example of apposition"
4.modification - an event that occurs when something passes from one state or phase to anothermodification - an event that occurs when something passes from one state or phase to another; "the change was intended to increase sales"; "this storm is certainly a change for the worse"; "the neighborhood had undergone few modifications since his last visit years ago"
acceleration - an increase in rate of change; "modern science caused an acceleration of cultural change"
deceleration, retardation, slowing - a decrease in rate of change; "the deceleration of the arms race"
happening, natural event, occurrence, occurrent - an event that happens
avulsion - an abrupt change in the course of a stream that forms the boundary between two parcels of land resulting in the loss of part of the land of one landowner and a consequent increase in the land of another
break - an abrupt change in the tone or register of the voice (as at puberty or due to emotion); "then there was a break in her voice"
mutation - a change or alteration in form or qualities
sublimation - (psychology) modifying the natural expression of an impulse or instinct (especially a sexual one) to one that is socially acceptable
surprise - a sudden unexpected event
nascence, nascency, nativity, birth - the event of being born; "they celebrated the birth of their first child"
breakup, separation, detachment - coming apart
vagary - an unexpected and inexplicable change in something (in a situation or a person's behavior, etc.); "the vagaries of the weather"; "his wealth fluctuates with the vagaries of the stock market"; "he has dealt with human vagaries for many years"
variation, fluctuation - an instance of change; the rate or magnitude of change
conversion - a change of religion; "his conversion to the Catholic faith"
death, decease, expiry - the event of dying or departure from life; "her death came as a terrible shock"; "upon your decease the capital will pass to your grandchildren"
decrease, lessening, drop-off - a change downward; "there was a decrease in his temperature as the fever subsided"; "there was a sharp drop-off in sales"
destabilization - an event that causes a loss of equilibrium (as of a ship or aircraft)
increase - a change resulting in an increase; "the increase is scheduled for next month"
easing, moderation, relief - a change for the better
deformation - alteration in the shape or dimensions of an object as a result of the application of stress to it
transition - a change from one place or state or subject or stage to another
transformation, transmutation, shift - a qualitative change
sparkling, twinkle, scintillation - a rapid change in brightness; a brief spark or flash
shimmer, play - a weak and tremulous light; "the shimmer of colors on iridescent feathers"; "the play of light on the water"
transmutation - (physics) the change of one chemical element into another (as by nuclear decay or radioactive bombardment); "the transmutation of base metals into gold proved to be impossible"
damage, impairment, harm - the occurrence of a change for the worse
development - a recent event that has some relevance for the present situation; "recent developments in Iraq"; "what a revolting development!"
revolution - a drastic and far-reaching change in ways of thinking and behaving; "the industrial revolution was also a cultural revolution"
chromosomal mutation, genetic mutation, mutation - (genetics) any event that changes genetic structure; any alteration in the inherited nucleic acid sequence of the genotype of an organism
sex change - a change in a person's physical sexual characteristics (as by surgery and hormone treatments)
loss of consciousness - the occurrence of a loss of the ability to perceive and respond

modification

modification

noun
The process or result of making or becoming different:
Translations
تَخْفيف، تَعْديلتَعْدِيلٌ
úpravasnížení
ændring
muunnos
modifikacija
smábreyting, lagfæring
変更
수정
modifikácia
ändring
การเปลี่ยนแปลงแก้ไข
değişiklikdeğiştirme
sự sửa đổi

modification

[ˌmɒdɪfɪˈkeɪʃən] Nmodificación f (to de)

modification

[ˌmɒdɪfɪˈkeɪʃən] nmodification f
to make modifications to sth → apporter des modifications à qch

modification

n(Ver)änderung f; (of design)Abänderung f; (of terms, contract, wording)Modifizierung f, → Modifikation f; to make modifications to something(Ver)änderungen an etw (dat)vornehmen; → etw abändern; → etw modifizieren; the suggested modifications to his designdie Änderungsvorschläge plzu seinem Entwurf

modification

[ˌmɒdɪfɪˈkeɪʃn] n modification (to, in)modifica (a)
to make modifications → fare or apportare delle modifiche

modify

(ˈmodifai) verb
to change the form or quality of, usually slightly. We had to modify the original design.
ˌmodifiˈcation (-fi-) noun

modification

تَعْدِيلٌ úprava ændring Änderung τροποποίηση modificación muunnos modification modifikacija modifica 変更 수정 wijziging endring modyfikacja modificação модификация ändring การเปลี่ยนแปลงแก้ไข değişiklik sự sửa đổi 修改

mod·i·fi·ca·tion

n. modificación, cambio.

modification

n modificación f; behavior — modificación de la conducta
References in periodicals archive ?
Objective: Cellular processes are largely governed by sophisticated protein posttranslational modification (PTM)-dependent signaling networks, and a systematic understanding of regulatory PTM-based networks is a key goal in modern biology.
Scientifically, there are circumstances where quantification of peptides using MRM will be preferred to traditional immunoassays for mutants, splice variants, and posttranslational modification, as antibodies against these specific changes to the protein primary structures will be difficult to generate.
GGTase I catalyzes the lipid posttranslational modification which is required for the function of Rho GTPases (frequently found aberrantly activated in human cancer).
Loss of balance in any of these posttranslational modification results in indefinite signals for excessive proliferation resulting in cancer (7).
The importance of this is that we showed, with a very tiny posttranslational modification, that we could restore visual function," Bhattacharya said.
Whereas protein drugs such as insulin and growth hormone are produced in bacterial cell lines, more complex proteins like erythropoietin or monoclonal antibodies have to be expressed in mammalian cell lines, as their activity depends on correct assembly and posttranslational modification.
Posttranslational modification of proteins; expanding nature's inventory.
Posttranslational modification of proteins is a critical part of molecular medicine.
According to Professor Steven Gygi of Harvard Medical School, 2DE/MS is "best suited to studying posttranslational modification.
biopharmaceuticals including MAbs and other proteins as well as posttranslational modification and glycan analysis.
Osteocalcin (OC), a vitamin K-dependent protein expressed by osteoblasts, contains 3 gamma-carboxyglutamic acid residues derived from the vitamin K-dependent posttranslational modification of glutamic acid residues.

Full browser ?