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(Biochemistry) the most abundant steroid in the human body, that is involved in the manufacture of testosterone, oestrogen, progesterone, and corticosterone

dehydroepiandrosterone (DHEA)

n dehidroepiandrosterona (DHEA)
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Effects of prasterone on corticosteroid requirements of women with systemic lupus erythematosus: a double-blind, randomized, placebo-controlled trial.
In addition, prasterone (Prestara), a synthetic form of dehydroepiandrosterone (DHEA), is being studied as a treatment for steroid-induced osteoporosis in women with lupus, and the drug LJP 394 (Riquent) may be able to block some of the antibodies that are believed to promote kidney disease in people with the disease.
Effects of oral prasterone (dehydroepiandrosterone) on single-dose pharmacokinetics of oral prednisone and cortisol suppression in normal women.
A medication combining the drug prasterone and the hormone dehydroepiandrosterone, or DHEA, stabilizes or improves symptoms of the autoimmune disease lupus, according to a study from a company in California.
Drugs profiles discussed in this report are sterol, estradiol hemihydrates, oxytocin, prasterone, RES-102, sinecatechins, TX-004HR, WC-3011.
DHEA, the most abundant steroidal hormone in the body, has been shown to lower TNF-alpha and IL-6 levels in the Prasterone (GL701) studies with lupus using a pharmaceutical form of DHEA.
7% in the lumbar spine and 2% in the hip among 24 women with lupus who took the adrenal androgen prasterone (also known as dehydroepiandrosterone or DHEA), compared with 31 women who received placebo.
Petri and her colleagues plan to evaluate the efficacy and safety of prasterone on BMD in women with lupus as a primary end point in a future 6-month trial.