Primary human preadipocytes
are a relevant tool to test the ability of chemicals to induce adipogenesis in human specimens and hence can identify a potential role for these chemicals to cause metabolic effects in humans (Boucher et al.
Retinoic acid inhibits adipogenesis via activation of Wnt signaling pathway in 3T3-L1 preadipocytes
These findings indicated that adipocytes and preadipocytes
express TSH receptors and that TSH induces preadipocytes
to release adipokines which plays an important role in the onset of metabolic syndrome and cardiovascular diseases.
Adipogenesis process consists of the differentiation of preadipocytes
to mature adipocytes which involves the accumulation of lipid droplets, changes in gene expression and cellular morphology (Bae et al.
Kurzer, Lignans and Flavonoids Inhibit Aromatase Enzyme in Human Preadipocytes
Mouse 3T3-L1 preadipocytes
were purchased from the Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.
Like neural development, adipogenesis --the process by which preadipocytes
proliferate and differentiate into mature adipocytes--is tightly regulated by a cascade of transcription factors that are expressed in response to stimuli, including nutrients.
Brandes, "Nox4 acts as a switch between differentiation and proliferation in preadipocytes
," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
However, macrophages are not only derived from the differentiation of preadipocytes
, but they can also arise from monocytes that diffuse through the subendothelial space via ICAM-1 and MCP-1 .
liver, bone, bile duct, kidney, intestinal mucosa and placenta), ALP is also expressed in adipose tissue which regulates intracellular fat deposition in preadipocytes
Expression of the TSH receptors has been found to be increased in orbital preadipocytes
EID1-induces brownlike adipocyte traits in white 3T3-L1 preadipocytes