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 (lī′gənd, lĭg′ənd)
An ion, molecule, or molecular group that binds to another chemical entity to form a larger complex.

[From Latin ligandus, gerundive of ligāre, to bind; see ligate.]


(ˈlɪɡənd; ˈlaɪ-)
(Chemistry) chem an atom, molecule, radical, or ion forming a complex with a central atom
[C20: from Latin ligandum, gerund of ligāre to bind]


(ˈlaɪ gənd, ˈlɪg ənd)

1. a molecule, as an antibody, hormone, or drug, that binds to a receptor.
2. a molecule, ion, or atom that is bonded to the central metal atom of a coordination compound.
[1945–50; < Latin ligandus, ger. of ligāre to bind, tie]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.ligand - a substance (an atom or molecule or radical or ion) that forms a complex around a central atom
substance - a particular kind or species of matter with uniform properties; "shigella is one of the most toxic substances known to man"
References in periodicals archive ?
Now in this project, nearly all of these various techniques and approaches will be combined in a new and so far unprecedented way and complemented by techniques used for protein ligand interactions and extreme low temperature measurements.
Proteros applied its industrial structural biology platform and proprietary technologies to deliver protein ligand structures to Almirall Scientists for a known, extremely challenging protein where little published data is available, particularly on solving specific protein ligand structures.
The CCDC also develops tools for use in the life sciences to aid drug discovery, these include GOLD, as well as SuperStar, for exploring protein ligand interactions, and Relibase+, a fully searchable database of crystallographic information about protein-ligand complexes derived from the PDB.
In many instances, antibody agonists and antagonists would be much easier to produce and work with in developing a drug candidate than the actual protein ligand regulating these pathways.