The New Medicine for Trypanosomatid Infections (NMTrypI) consortium uses a highly interdisciplinary approach to optimize pteridine
, benzothiazole and miltefosine derivatives, as well as natural products against Trypanosomatids.
These results indicate that abnormal pteridine
metabolism contributes to causing endothelial dysfunction and the enhancement of vascular oxidative stress in the insulin-resistant state.
Neopterin, a pteridine
derivative secreted by interferon-gammastimulated macrophages, is used as a biochemical marker for cellular immune response.
During the study, the researchers identified six pteridine
derivatives, compounds that help regulate the metabolism of cells, in the urine samples.
Environmental control of seasonal variation in the butterfly Colias eurytheme: effects of photoperiod and temperature on the pteridine
These compounds have similar chemical structures, consisting of a reduced pteridine
moiety coupled through a methylene group to p-aminobenzoic acid (pABA) , to which glutamic acid is attached via an amide bond.
Sulfonamides inhibit one of the integral enzymes in folate synthesis, dihydropteroate synthase (DHPS), which catalyzes the condensation of para-aminobenzoic acid and pteridine
to form dihydropteroic acid (Figure).
This multimeric enzyme, which functions in the synthesis of pteridine
eye pigments as well as BH4 cofactor, exists as multiple isoforms that are expressed in a developmentally and functionally specific manner (O'Donnell et al.
both the melanins and the pteridine
compounds that generate the reds and yellows are by-products of metabolic activity that took place when the cells were still alive in the late pupa stage.
It is a book for the libraries of research institutes and universities, primarily of interest to chemists, medicinal chemists, and biochemists engaged in pteridine
Neopterin, a pteridine
derivative produced by activated macrophages in response to stimulation by interferon-[gamma], is a marker of both immune activation and coronary artery disease (CAD) activity (2).
MTXPG photolytic product (hypothetically a pteridine
carboxylic acid) was measured at an excitation wavelength set at 274 nm and an emission wavelength set at 470 nm.