The folic acid chemical structure consists of a pteridine
ring, a p-aminobenzoic acid, and a molecule of L-glutamic acid (2,3).
Among the biomarkers for diagnosis and prognosis in AMI, the Neopterin, a pteridine
derivative is considered to be one of the new novel biomarkers, which is found to be elevated in patients with AMI (1).
2,5,8,13) Folates also differ from folic acid "in the extent of the reduction state of the pteroyl group, the nature of the substituents on the pteridine
ring and the number of glutamyl residues attached to the pteroyl group.
The New Medicine for Trypanosomatid Infections (NMTrypI) consortium uses a highly interdisciplinary approach to optimize pteridine
, benzothiazole and miltefosine derivatives, as well as natural products against Trypanosomatids.
These alkaloids include quinazoline, quinaxaline, cinnoline, phthalazine and other three or four membered ring azaheterocycles such as, pteridine
, alloxazine, isoalloxazine .
These results indicate that abnormal pteridine
metabolism contributes to causing endothelial dysfunction and the enhancement of vascular oxidative stress in the insulin-resistant state.
The carotenoid-based and pteridine
pigments found in the pigmented skin of L.
Leishmania donovani: oral therapy with glycosyl 1,4-dihydropyridine analogue showing apoptosis like phenotypes targeting pteridine
reductase 1 in intracellular amastigotes.
Neopterin, a pteridine
derivative secreted by interferon-gammastimulated macrophages, is used as a biochemical marker for cellular immune response.
During the study, the researchers identified six pteridine
derivatives, compounds that help regulate the metabolism of cells, in the urine samples.
Environmental control of seasonal variation in the butterfly Colias eurytheme: effects of photoperiod and temperature on the pteridine
These compounds have similar chemical structures, consisting of a reduced pteridine
moiety coupled through a methylene group to p-aminobenzoic acid (pABA) , to which glutamic acid is attached via an amide bond.