cytoplasmic antibody type 1 (PCA-1), also known as anti-Yo, is highly specific and the most frequently detected autoantibody in PCA (5, 8).
This study demonstrates that Purkinje cell
protein-4 (Pcp4) is not only important in maintaining the heart's normal rhythmic behavior, but that when Pcp4 expression is reduced, it short-circuits electrical activity in a small but critical population of cells in the heart muscle, leading to cardiac arrhythmias," said Glenn I.
Although zinc supplementation in one study did not mitigate alcohol-induced cerebellar Purkinje cell
loss following developmental alcohol exposure (Chen et al.
Effect of prenatal exposure to diclofenac sodium on Purkinje cell
numbers in rat cerebellum: A stereological study.
Another interesting pattern in the cerebellum was seen for MABs 12C4 (J), 12D11 (K), and 7E6 (L), wherein the wide, sinusoidal-shaped area containing the Purkinje cell
layer was particularly obvious because of the lack of any reaction product.
The cerebellar folia also had widespread lesions, with a predilection for Purkinje cell
necrosis and loss, with characteristic Bergmann glial and microglial proliferation and dendritic spheroids in the overlying layer; however, axonal torpedoes were rarely found (Figure 4).
Roman (2007) hypothesized that even transient intrauterine deficits in thyroid hormones (as little as 3 days) at critical points in gestation could alter the cortical architecture, interfering with neuronal migration and Purkinje cell
growth, indications of both of which have been observed in autopsy studies of autism (Fatemi et al.
damage by many post puberty diseases such as seizure, Alzheimer's and Huntington considered relevant that called Cerebellar congenital affective syndrome.
Investigations using animal models have determined that the rate of acquisition of Pavlovian conditioning is diminished proportionate to cerebellar Purkinje cell
loss (Brown et al.
MAPPING THE PURKINJE CELL
DEGENERATION (PCD) LOCUS IN MUTANT MICE.
Additional studies of cerebellar tissue were sought, including immunofluorescence (Figure 3, cerebellum, arrow identifies Purkinje cell
, original magnification x160) and electron microscopy (Figure 4, cerebellum, original magnification x40 000).
A key element in these circuits is a particular cell type called the Purkinje cell