Of significance is the role that quorum sensing
plays in pathogenesis.
How bacteria talk to each other: Regulation of gene expression by quorum sensing
SAN DIEGO -- Pico Pharmaceuticals today announced a publication in the journal Nature Chemical Biology that supports a novel mechanism for the inhibition of quorum sensing
pathways in bacterial pathogenesis.
In earlier work, Givskov and his colleagues showed that "crude extracts of garlic inhibit the expression of a large number of genes that are controlled by bacterial quorum sensing
[communication among bacterial cells involved in biofilm development], and that extracts promote a rapid clearing of pulmonary Pseudomonas aeruginosa infection in mice," he says.
in beneficial plant-bacteria associations
As the number of bacteria present grows, signaling molecules involved in quorum sensing
Much of the development and structural integrity of the biofilm is dependent upon quorum sensing
After a brief introduction to the discipline, contributors offer 12 papers describing their advanced research in biofilms, including the biofilm mode of life, the initial transition to a surface lifestyle by pseudomonada, the biofilm matrix, cyclic di-GMP as an intracellular signal regulating bacterial biofilm formation, N-acylhomoserine lactones and their relationship with quorum sensing
and biofilm development in gram-negative bacteria, signaling in e-coli biofilms, peptide signaling, differentiation and dispersal in biofilms, human oral multi-species biofilms and their bacterial communities in health and disease, biofilms as refuges against predation, biofilms on plant surfaces and bacterial biofilms on fungal surfaces.
in Bacteria: Potential in Plant Health Protection
We used Cecropia pachystachya Trecul to search for quorum sensing
(QS) inhibitors compounds and found that the aqueous extract of C.
Nunez asserted that the bacteria do not likely produce it to cause disease, but produce it in response to an increase in neighboring bacteria - something called quorum sensing
Using this newly developed chemical tool, analogs of natural products with confirmed quorum sensing
or anticancer properties will be synthesized.