clinical trial

(redirected from Randomized controlled trial)
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Noun1.clinical trial - a rigorously controlled test of a new drug or a new invasive medical device on human subjects; in the United States it is conducted under the direction of the FDA before being made available for general clinical use
trial, run, test - the act of testing something; "in the experimental trials the amount of carbon was measured separately"; "he called each flip of the coin a new trial"
phase I, phase I clinical trial - a clinical trial on a few persons to determine the safety of a new drug or invasive medical device; for drugs, dosage or toxicity limits should be obtained
phase II, phase II clinical trial - a clinical trial on more persons than in phase I; intended to evaluate the efficacy of a treatment for the condition it is intended to treat; possible side effects are monitored
phase III, phase III clinical trial - a large clinical trial of a treatment or drug that in phase I and phase II has been shown to be efficacious with tolerable side effects; after successful conclusion of these clinical trials it will receive formal approval from the FDA
phase IV, phase IV clinical trial - sometimes the FDA approves a drug for general use but requires the manufacturer to continue to monitor its effects; during this phase the drug may be tried on slightly different patient populations than those studied in earlier trials
References in periodicals archive ?
Total extraperitoneal inguinal hernia repair compared with Lichtenstein (the level-trial): a randomized controlled trial.
Intracoronary infusion of Wharton's jelly-derived mesenchymal stem cells in acute myocardial infarction: double-blind, randomized controlled trial," BMC Medicine, 2015, 13:162, DOI: 10.
Assessment of adherence to the CONSORT statement for quality of reports on randomized controlled trial abstracts from four high-impact general medical journals.
Researchers conducted a randomized controlled trial to determine whether preapplication of lidocaine-epinephrine-tetracaine would decrease pain in children undergoing repair of minor cuts with tissue adhesive.
Data Source: First randomized controlled trial comparing robotic-assisted and laparoscopic hysterectomy in 53 women.
Acupuncture for depression during pregnancy: a randomized controlled trial, Obstetrics & Gynecology, 2010, 115(3):511-520.
1b: Individual randomized controlled trials (with narrow confidence interval)
It's clear that the randomized controlled trial is a powerful tool for determining the usefulness of a discrete intervention such as a medication.
Effect of estrogen plus progestin on global cognitive function in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial.
The authors believe this is the first randomized controlled trial of community rehabilitation following severe TBI.
This instalment of Sex Research Update summarizes recent research on the cost-utility analysis of condom social marketing campaigns; changes in the sexual behaviour of high school students in the United States from 1991 to 2001; a randomized controlled trial evaluation of a teen pregnancy prevention program; a randomized controlled trial evaluation of a sexual risk reduction intervention for drug dependent adolescents; condom specific sexual assertiveness among heterosexually active men; young adults' recollections of sexual experiences in childhood; the impact of vasectomy on sexual and marital satisfaction; and the sexual behaviour of physically disabled adolescents.
The authors examine, for example, one randomized controlled trial of swimming exposure conducted in the United Kingdom in which swimmers became ill even on days when concentrations of fecal coliform bacteria were at acceptable levels.

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