clinical trial

(redirected from Randomized controlled trial)
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Noun1.clinical trial - a rigorously controlled test of a new drug or a new invasive medical device on human subjects; in the United States it is conducted under the direction of the FDA before being made available for general clinical use
trial, run, test - the act of testing something; "in the experimental trials the amount of carbon was measured separately"; "he called each flip of the coin a new trial"
phase I, phase I clinical trial - a clinical trial on a few persons to determine the safety of a new drug or invasive medical device; for drugs, dosage or toxicity limits should be obtained
phase II, phase II clinical trial - a clinical trial on more persons than in phase I; intended to evaluate the efficacy of a treatment for the condition it is intended to treat; possible side effects are monitored
phase III, phase III clinical trial - a large clinical trial of a treatment or drug that in phase I and phase II has been shown to be efficacious with tolerable side effects; after successful conclusion of these clinical trials it will receive formal approval from the FDA
phase IV, phase IV clinical trial - sometimes the FDA approves a drug for general use but requires the manufacturer to continue to monitor its effects; during this phase the drug may be tried on slightly different patient populations than those studied in earlier trials
References in periodicals archive ?
In a randomized controlled trial with 338 patients, Chinese researchers sought to understand the efficacy of acupuncture with weak stimulation or strong (de qi) stimulation.
HIV/STD risk reduction interventions for African American and Latino adolescent girls at an adolescent medicine clinic: a randomized controlled trial, Archives of Pediatrics and Adolescent Medicine, 2005, 159(5):440-449.
The POSCH trial was the first randomized controlled trial to show the life-sustaining benefits of cholesterol lowering and it is the only trial with 25 years of follow-up," Buchwald said.
Protection against sexually transmitted diseases by granting sex workers in Thailand the choice of using the male or female condom: results from a randomized controlled trial, AIDS, 1998, 12(14):1851-1859.
Effects of red ginseng supplementation on menopausal symptoms and cardiovascular risk factors in postmenopausal women: a double-blind randomized controlled trial.
Nor, in spite of its being a randomized controlled trial, did the authors make any new clinical recommendations for the people who paid for their study: the citizens of the US.
Modifying the Yuzpe regimen of emergency contraception: a multicenter randomized controlled trial, Obstetrics & Gynecology, 2003, 101(6):1160-1167.
1) The strongest predictors of female condom use that emerged in a randomized controlled trial of a multisite intervention aimed at reducing women's risk of HIV and other sexually transmitted diseases (STDs) were having had instruction and skills training, and intending to use the method.
A phase III, multicenter, randomized controlled trial of panitumumab plus best supportive care (BSC) versus BSC alone in patients with metastatic colorectal cancer.
Effect of nonoxynol-9 on urogenital gonorrhea and chlamydial infection: a randomized controlled trial, JAMA, 2002, 287(9):1117-1122.
Miller L and Notter KM, Menstrual reduction with extended use of combination oral contraceptive pills: randomized controlled trial, Obstetrics & Gynecology, 2001, 98(5, pt.

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