SCID


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SCID

abbr.
severe combined immunodeficiency

SCID

abbreviation for
(Pathology) severe combined immune deficiency; a serious condition in which babies are born with reduced numbers of T- and B-lymphocytes, which impairs their immune systems and makes them susceptible to severe infections and cancer
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.SCID - a congenital disease affecting T cells that can result from a mutation in any one of several different genes; children with it are susceptible to infectious disease; if untreated it is lethal within the first year or two of life
immunodeficiency - immunological disorder in which some part of the body's immune system is inadequate and resistance to infectious diseases is reduced
monogenic disease, monogenic disorder - an inherited disease controlled by a single pair of genes
ADA-SCID - SCID resulting from mutation of a gene that codes for adenosine deaminase
X-linked SCID, X-SCID - SCID in male children resulting from mutation of a gene that codes for a protein on the surface of T cells that allows them to develop a growth factor receptor
References in periodicals archive ?
Severe combined immunodeficiency (SCID) met all seven criteria that Wisconsin has in place to determine whether a newborn screen should be instituted, including the availability of a low-cost test (about $6 per specimen), a reliable confirmatory test, a clinically significant disease that can be successfully treated (by transplanting hematopoietic stem cells), and a neonatal incidence rate of at least one case per 100,000 live births (the actual rate for SCID is one case in every 66,000 live births).
The high level of engraftment was evident in the 9 treated NOD SCID mice by the presence of 2- 13 % human CD45 cells.
SCID is a genetic disease that forces patients to breathe filtered air and avoid human contact as the natural defences of their bodies are too weak to combat germs.
As the result of this transaction, the transfer of all of Sony's domestic and overseas operations of the chemical products businesses, including all shares in SCID, to DBJ has been completed, and Sony has received 57.
Physicians at Hopital Necker Enfants Malades in Paris now have successfully treated SCID in 4 of 5 infants by removing bone marrow from the babies, correcting the genetic flaw in immature immune cells, and then reintroducing the corrected cells.
In SCID cases where treatment is generally bone marrow transplant, early diagnosis is critical since treatment outcome is better when the procedure is performed before the child experiences serious infection.
Puck's work on her SCID screening technique was recently published; see "Development of population-based newborn screening for severe combined immunodeficiency", J Allergy Clin Immunol 2005;115:391-8.
Fischer and his co-authors said the findings "pave the way" for the treatment of other genetic diseases, including other varieties of SCID.
Marina Cavazzana-Calvo, MD of Hopital Necker in Paris, France and colleagues treated 4 SCID patients age 3 weeks to 7 months, all with severe sepsis and no available bone marrow donor, with transplants of their own genetically-altered CD34 bone marrow cells.
Retrieved islet-like clusters from diabetic SCID mice contain insulin positive cells and secrete insulin upon glucose challenge with concurrent human C-peptide secretion.
Moreover, in most institutions where placental blood transplantation is performed for the treatment of SCID, chemotherapy is given before the procedure and prophylaxis against GVHD is given for 9 months afterward.
Talabostat suppressed tumor growth for at least 30 days in SCID mice, whereas in neutrophil-depleted SCID mice, talabostat had no significant effect.