Biologists introduce the underlying foundations and basic mechanisms of signal transduction
in animal cells to advanced students, to investigators new to the field, and to researchers actively working in the general area.
Transformation of breast cells occurs through loss or mutation of tumor suppressor genes, or activation or amplification of oncogenes, leading to deregulation of signal transduction
pathways, abnormal amplification of growth signals, and aberrant expression of genes that ultimately transform the cells into invasive cancer.
Two-component systems are the predominant signal transduction
devices of Eubacteria, and their simple molecular architecture allows them to be employed in many different cellular processes.
The grant will support the Center of Biomedical Research Excellence (CoBRE) for Signal Transduction
and Cancer, led by Laura F.
The nine chapters in this volume fall under the broad heading of research in signal transduction
, with studies specifically discussing neurotrophins, the signaling functions of reactive oxygen and nitrogen species, cell traction forces, impedance matching, oxidative stress and its role in the modulation of cell death and liver injury, MAPK signaling pathways as targets for gastrointestinal cancer therapy, angiogenesis, apoptic signal transduction
of brain glia cells, and the role of receptor-like kinases.
introduces two additions to its line of cell signal transduction
reagents-Phospho-MAPKAPK-2 and Phospho-STAT3 kinase antibodies.
BASF Plant Science GmbH (Ludwigshafen, Germany) has patented a transgenic plant transformed by a Signal Transduction
Stress-Related Protein coding nucleic acid, wherein expression of the nucleic acid sequence in the plant results in increased tolerance to environmental stress as compared to a wild type variety of the plant.
It has been established that the signal transduction
pathway for steroid hormones involves interaction of the hormone--receptor complex with sites on DNA to promote or suppress the expression of specific genes.
TAK-242 is a compound that suppresses the production of inflammatory mediators including cytokine by the signal transduction
mediated by Toll-like receptor (TLR4).
The company currently offers 10 unique signal transduction
protein profiling services for tracking over 180 protein kinases, 130 known phosphorylation site targets of kinases and 110 other signalling proteins that regulate cell proliferation, stress and death.
Little is known about the components of signal transduction
pathway that link these events.
AxCell Biosciences, of Newtown, PA, a subsidiary of Cytogen Corporation, is engaged in the research and development of novel biopharmaceutical products using its growing portfolio of functional proteomics solutions and collection of proprietary signal transduction