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 (sûr′to͞o-ĭn, -tyo͞o-)
Any of a family of enzymes that occur in all living organisms and are thought to regulate cellular aging, apoptosis, and resistance to stress in more complex eukaryotic organisms.

[Alteration of Sir2, name of the first gene coding for the synthesis of such enzymes to be isolated (short for s(ilent mating-type) i(nformation) r(egulation) 2, so called because the gene silences the expression of genes relating to the two mating types of the yeast from which it was isolated ) + -in.]


a protein that regulates cell metabolism and ageing
References in periodicals archive ?
Resveratrol favorably enhances the activation of cellular sirtuin proteins.
Keywords: Rheumatoid arthritis, sirtuin 2, sirtuin 3
The molecule delivers resveratrol, which activates the Sirtuin and P53 genes - the master guardian genes inside our cells that suppress tumour formation and have shown therapeutic benefits.
Sirtuin The activate genes are special because they orchestrate processes deep within our cells that influence our susceptibility to disease and how long we live.
One potential method to reduce oxidative stress in MSCs is by modulating sirtuin expression and/or activity.
Mammalian Sirtuin family contains 7 members (named SIRT1-SIRT7) and is endowed to diverse biological functions in different cellular compartments.
This potential path to the fountain of youth first appeared in 1999, with the suggestion that lifespan was dramatically extended in yeast bearing an extra copy of sirtuin, the conserved enzyme class.
SIRT4, a less studied mitochondrial sirtuin, is an integral part of the metabolic response to genotoxic stress.
Proteins known as sirtuins are necessary to achieve this life span extension, with sirtuin 1, or SIRT1, often regarded as the most important.
Research has demonstrated that increasing the levels of NAD+ can support healthy aging by stimulating mitochondrial energy production, as well as by activating sirtuin function.
28 ( ANI ): A new study has found that activating a protein called sirtuin 1 extends lifespan, delays the onset of age-related metabolic diseases, and improves general health in mice.
A team of scientists at the National Institutes of Health in US conducted experiments on mice models and found that a protein called sirtuin 1 (SIRT1) played a major role in ageing process.