Smith Hamilton Othanel

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Smith (sm

th), Hamilton Othanel Born 1931.

American microbiologist who isolated bacterial enzymes that could split genetic DNA into fragments large enough to retain genetic information but small enough to permit chemical analysis. The existence of these compounds (called restriction enzymes) was earlier predicted by Werner Arber, and their discovery revolutionized genetic engineering. For this work Smith shared the 1978 Nobel Prize for physiology or medicine with Arber and Daniel Nathans.

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