Neutrophil Changes Erythrocyte Changes Cytoplasmic vacuoles Crenated (burr cells, echinocytes) Loss of granulations Spherocytes
Elongated nuclei Elongated (elliptocytes) (loss of segmentation) Undefined chromatin Schistocytes (fragments) (appear liquefied) Pyknotic nuclei (necrobiotic) Hypochromic Cytoplasm rupture Smudge (basket) cells
Abnormal red blood cells (RBCs) with low volume, including microcytes, schistocytes, and spherocytes
, have been reported to be the cause of spuriously high platelet counts.
morphological alteration of erythrocytes, characterized by the formation of echinocytes and spherocytes
and such changes were not seen in the control group (figure 1A and B).
1A, modified erythrocytes, such as spherocytes
, cup-shaped cells and echinocytes were ubiquitous in the blood of septic patients but absent in volunteers (Fig.
Pencil cells Iron deficiency Stomatocytes Artifact (due to slow drying in humid environment), Liver disease, alcoholism, Rh-null disease, Obstructive lung disease Elliptocytes Hereditary Elliptocytosis (>25%) Bite cells (degmacytes) G6PD deficiency, Oxidative stress, unstable haemoglobins, congenital heinz body anaemia Basket cells (half ghost Oxidant damage, G6PD deficiency, cells/Blister cells) Unstable haemoglobins Spherocytes
Hereditary spherocytosis, ABO incompatibility, Autoimmune hemolytic anemia (warm antibody type), Severe burns Teardrop red cell Idiopathic myelofibrosis, (dacrocytes, myelophthisic anaemia, lacrymocytes) thalassemias
5] /[micro]L) severe non- regenerative anemia along with mature neutrophila, crenation of erythrocytes and spherocytes
with adequate number of platelets.
HPP is characterized by erythrocyte poikilocytosis and fragmentation, erythrocyte budding, spherocytes
, triangulocytes, micropoikilocytosis, microspherocytosis, and occasional elliptocytes, which together result in a pattern reminiscent of thermal injury.
gondii infection, RBC destruction does not appear to be a mechanism for anemia, as there are no detectable spherocytes
or schistocytes, hallmarks of such destruction, [sup] in peripheral blood smears from infected mice (data not shown).
Haemolysis was confirmed by the detection of marked numbers of schistocytes, moderate numbers of spherocytes
and mild polychromasia on blood film, and elevated serum lactate dehydrogenase and bilirubin (Figures 1 and 2).
The peripheral blood film showed dimorphic picture with polychromasia, nucleated RBCs and spherocytes
1) showed a leukoerythroblastic picture with marked polychromasia, large number of circulating nucleated red blood cells and marked poikilocytosis including blister cells, spherocytes
and echinocytes, consistent with oxidative hemolysis.
Peripheral smear showed severe anisocytosis, macrocytosis with microcytic RBC population and spherocytes
, Nucleated RBCs= 3/ 100 WBCs, neutrophilia with hypersegmented neutrophils, metamyelocytes and myelocytes.