The drug in question, cadazolid, is a novel quinoxolidinone antibiotic that has demonstrated efficacy as a strong inhibitor of Clostridium difficile protein synthesis, which results in the suppression of toxin production and spore formation
The blue itself inhibits the spore formation
in glass beads.
However, we have recently shown that at least one week following spore formation
, during an adaptive period, the spore senses and responds to environmental cues and undergoes corresponding molecular changes, influencing subsequent emergence from quiescence.
Microbiologists summarize the current understanding of bacterial spores, integrating several decades of research about the process of spore formation
in the model organism </B.
The persistence of infection might be explained by a questionable initial antimicrobial drug regimen but also by spore formation
and/or poor diffusion of antimicrobial drugs, as suggested by the presence of necrotic tissues such as the bone sequestrum.