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Related to Systemic scleroderma: systemic lupus erythematosus


A pathological thickening and hardening of the skin.


(ˌsklɪərəʊˈdɜːmə) ,




(Pathology) a chronic progressive disease most common among women, characterized by a local or diffuse thickening and hardening of the skin
[C19: from New Latin sclerōdermus, from Greek, from sklēros hard + derma skin]


(ˌsklɪər əˈdɜr mə, ˌsklɛr-)

a disease in which connective tissued becomes hardened and rigid.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.scleroderma - an autoimmune disease that affects the blood vessels and connective tissuescleroderma - an autoimmune disease that affects the blood vessels and connective tissue; fibrous connective tissue is deposited in the skin
autoimmune disease, autoimmune disorder - any of a large group of diseases characterized by abnormal functioning of the immune system that causes your immune system to produce antibodies against your own tissues
morphea - localized scleroderma
2.Scleroderma - genus of poisonous fungi having hard-skinned fruiting bodies: false truffles
fungus genus - includes lichen genera
family Sclerodermataceae, Sclerodermataceae - a family of fungi or order Sclerodermatales with a single-layered peridium; includes earthballs
earthball, hard-skinned puffball, puffball, false truffle - any of various fungi of the genus Scleroderma having hard-skinned subterranean fruiting bodies resembling truffles
Scleroderma aurantium, Scleroderma citrinum - an earthball fungus that is a dingy brownish yellow and a dark purplish interior; the peridium is covered with a pattern of small warts
Scleroderma flavidium, star earthball - an earthball with a smooth upper surface that is at first buried in sand; the top of the fruiting body opens up to form segments like the ray of an umbel
Scleroderma bovista, smooth earthball - an earthball with a peridium that is firm dry and smooth when young but developing cracks when mature; pale orange-yellow when young and reddish brown at maturity


n. escleroderma, esclerodermia, induración y casi total atrofia de la epidermis.


n esclerodermia, esclerosis sistémica progresiva; localized — esclerodermia localizada
References in periodicals archive ?
Pterygium inversum is usually seen in systemic scleroderma and with systemic lupus erythematosus.
There are two main types of the disease: the localized form (called localized scleroderma, limited scleroderma, or morphea) and the systemic form (called systemic scleroderma, diffuse scleroderma, generalized scleroderma, or systemic sclerosis).
There are, unquestionably, risks with transplant, but the SCOT findings support myeloablative autologous HSCT as a significant advance in the care of diffuse cutaneous systemic scleroderma with internal organ involvement, as this approach provided superior long-term outcomes, compared with 12 months of IV cyclophosphamide, he said, adding that the global rank composite score developed for this study was a useful measure of scleroderma outcomes.
Her form of systemic scleroderma can also affect the internal organs, including the heart, kidneys and bowel.
announced today that it received from the Minister of Health, Labour and Welfare, a notification of orphan drug designation for human anti-human IL-6 receptor monoclonal antibody "tocilizumab," a drug under development for treatment of systemic scleroderma.
Pulmonary fibrosis, the lung involvement of the disease, contributes the development of the PAH in patients with systemic scleroderma.
Previous studies have reported the association between AITDs and systemic scleroderma, an autoimmune connective tissue disorder characterized by systemic inflammation, microvascular abnormalities, and fibrosis of the skin and internal organs [7-10].
Skin biopsy: Punch biopsy was done in the relevant cases such as Myxoedema, Systemic scleroderma, Lichen planus, Morphea etc.
Keywords: Systemic scleroderma, Scleroderma renal crisis, Angiotensin-converting enzyme inhibitors.
If it goes untreated, systemic scleroderma may be fatal within a few years of onset.
The aim of our study was to search for APLs in patients affected by systemic scleroderma and to evaluate their involvement in the clinical manifestations of this disease.
Nearly all patients with systemic scleroderma will have esophageal disease, and extraesophageal manifestations can appear as mouth ulcers, chronic cough, and recurrent pneumonia, she reported.