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Related to Systemic scleroderma: systemic lupus erythematosus


A pathological thickening and hardening of the skin.


(ˌsklɪərəʊˈdɜːmə) ,




(Pathology) a chronic progressive disease most common among women, characterized by a local or diffuse thickening and hardening of the skin
[C19: from New Latin sclerōdermus, from Greek, from sklēros hard + derma skin]


(ˌsklɪər əˈdɜr mə, ˌsklɛr-)

a disease in which connective tissued becomes hardened and rigid.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.scleroderma - an autoimmune disease that affects the blood vessels and connective tissuescleroderma - an autoimmune disease that affects the blood vessels and connective tissue; fibrous connective tissue is deposited in the skin
autoimmune disease, autoimmune disorder - any of a large group of diseases characterized by abnormal functioning of the immune system that causes your immune system to produce antibodies against your own tissues
morphea - localized scleroderma
2.Scleroderma - genus of poisonous fungi having hard-skinned fruiting bodies: false truffles
fungus genus - includes lichen genera
family Sclerodermataceae, Sclerodermataceae - a family of fungi or order Sclerodermatales with a single-layered peridium; includes earthballs
earthball, hard-skinned puffball, puffball, false truffle - any of various fungi of the genus Scleroderma having hard-skinned subterranean fruiting bodies resembling truffles
Scleroderma aurantium, Scleroderma citrinum - an earthball fungus that is a dingy brownish yellow and a dark purplish interior; the peridium is covered with a pattern of small warts
Scleroderma flavidium, star earthball - an earthball with a smooth upper surface that is at first buried in sand; the top of the fruiting body opens up to form segments like the ray of an umbel
Scleroderma bovista, smooth earthball - an earthball with a peridium that is firm dry and smooth when young but developing cracks when mature; pale orange-yellow when young and reddish brown at maturity


n. escleroderma, esclerodermia, induración y casi total atrofia de la epidermis.


n esclerodermia, esclerosis sistémica progresiva; localized — esclerodermia localizada
References in periodicals archive ?
It also describes how lesser-known factors like hormone replacement therapy, hiatal hernia and connective tissue disorders like systemic scleroderma or sclerosis play a role.
The aim of our study was to search for APLs in patients affected by systemic scleroderma and to evaluate their involvement in the clinical manifestations of this disease.
Nearly all patients with systemic scleroderma will have esophageal disease, and extraesophageal manifestations can appear as mouth ulcers, chronic cough, and recurrent pneumonia, she reported.
In fact, gouty arthritis is uncommon in systemic lupus erythematosus, systemic scleroderma and rheumatoid arthritis (RA) (1-5).
Hope Barrie, 14, suffers from Raynaud's systemic scleroderma - which causes her skin to tighten and harden as it gets colder, leaving her body and joints feeling permanently frozen and numb.
Systemic scleroderma in Greece: low mortality and strong linkage with HLA-DRBI * 1104 allele.
The acute form of systemic scleroderma can spread to the organs, leaving Hope, of Tarbolton, Ayrshire, facing a race against time to find a cure.