helper T cell

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helper T cell

n.
Any of a class of T cells that are activated by interacting with antigen-presenting cells, such as a dendritic cells, and then function to activate other cells of the immune system, including B cells, cytotoxic T lymphocytes, and phagocytes. Activated helper T cells usually have CD4 receptors on the surface. Also called T-helper cell.

helper T cell


n.
any of a group of T cells that activate the immune system either by enhancing the production of antibody and other T cells or by mobilizing macrophages to engulf invading particles.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.helper T cell - T cell with CD4 receptor that recognizes antigens on the surface of a virus-infected cell and secretes lymphokines that stimulate B cells and killer T cells; helper T cells are infected and killed by the AIDS virus
T cell, T lymphocyte - a small lymphocyte developed in the thymus; it orchestrates the immune system's response to infected or malignant cells
References in periodicals archive ?
However, the PHI group did exhibit stronger T helper cell responses, which led the researchers to suggest that "individuals treated in early infection may benefit from [therapeutic] strategies aimed at enhancing virus-specific CTL responses, whereas individuals treated later in infection may benefit from strategies aimed at enhancing HIV-1-specific T helper cell functions as well as broadening CTL responses to combat increased viral diversity.
The study demonstrates that MUC-1 in the form of an immune complex is more efficiently processed than MUC-1 alone, leading to T helper cell stimulation and an enhanced cytotoxic T lymphocyte (CTL) response.
Our findings, in both animal and human models, indicate that the type of T helper cell present is the determining factor in predicting whether interferon-_ will be effective," Raman added.
By understanding the role Stat4 plays in IL-12 signaling and T helper cell differentiation, we have achieved the first steps in a new approach to treating immune-mediated diseases," said David V.
To our knowledge, this is the first transcription factor that appears to regulate this switching of T helper cell phenotypes.
David Hafler (both Yale University, New Haven and the Broad Institute of the Massachusetts Institute of Technology, MIT, and Harvard University, USA) observed changes in CD4 positive T helper cells (Th) in humans, which were associated with specific dietary habits.