T-helper cell


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Related to T-helper cell: Effector T cells, T cytotoxic cells

T-help·er cell

 (tē′hĕl′pər)
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It attenuates the T-helper cell Type 1 response causing suppression of cytokines such as IL-1, IL-6, interferon-[gamma] (INF), and tumor necrosis factor-[alpha] (TNF).
Peripheral T-cell lymphomas of follicular T-helper cell derivation with Hodgkin/Reed-Sternberg cells of B-cell lineage: both EBV-positive and EBV-negative variants exist.
They discovered that naive, activated, and effector T-killer and T-helper cell populations occurred in similar percentages in the virus-infected patients and RA patients but not in the healthy controls.
93) What this means is that too many regulatory T-cells form while T-helper cell counts drop, resulting in there being more regulatory T-cells than T-helpers.
The reactions included: (1) Reaction with T-lymphocyte (CD-3); (2) reaction with T-helper cell (CD-4); (3) reaction with T-suppressing cell (CD-8); (4) reaction with B-lymphocyte (CD-20).
As tuberculous disease is initiated and advances in the body, there appears to be a shift from a T-helper cell type 1 (TH1) protective response to a T-helper cell type 2 (TH2) pathway which is less effective and more injurious to tissue.
The T-helper cell differentiation pathway included the Fc-receptor ([up arrow], DEX, DES, CPS, TCDD), CD28 ([down arrow], DEX, DES, CPS), and histocompatibility ([up arrow], DEX, TCDD) genes, but no other genes altered in the TCR or CD28 signaling pathways.
Type I T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease.
Since specific subsets of T-helper cells drive specific and qualitatively different adaptive immune responses, T-helper cell cytokines have been grouped in different categories which potentially cross-inhibit each other.
TFN-[alpha] is involved in maintaining a T-helper cell type 1 immune response because it induces production of interleukin-12 (IL- 12) and IL- 18, with subsequent production of fungicidal interferon-[gamma] (8).
A growing data set suggests that pre- and probiotic supplementation in infancy can enhance IgA responses to antigenic challenge, and favorably influence T-helper cell balance, thus reducing inflammatory and/or allergic responses.
Clear psoriasis faster than conventional phototherapy, and may become predominant in the future CNTO-1275 Anti-interleukin-12 antibody that switches the immune response from a T-helper cell 1 cytokine reaction most commonly seen in psoriasis to a T-helper cell 2 cytokine response T-cell receptor vaccines Have been developed and are undergoing clinical trials in patients with psoriasis Pimecrolimus Used orally.