thp

(redirected from Tamm-Horsfall protein)
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Related to Tamm-Horsfall protein: Tamm-Horsfall mucoprotein

thp

also t.hp.
abbr.
thrust horsepower
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Studies have also demonstrated that renal epithelial cells respond to increased CaOx crystal formation by producing macromolecular proteins, such as p38, OPN, hyaluronic acid, a-1-microglobulin, Tamm-Horsfall protein, and prothrombin fragment-1, which subsequently affect the crystal deposition process [12, 20].
As a consequence, large amounts of FLCs reach the distal tubule lumen where they interact specifically with Tamm-Horsfall proteins (THPs; also known as uromodulin), generating myeloma casts.
13,14) In a Dalmatian dog model, decreased urinary excretion of 2 urine inhibitors of crystallization, Tamm-Horsfall protein and glycosaminoglycans, were found in dogs with a tendency to develop uric acid calculi.