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therapeutic index
(redirected from Therapeutic margin)

    Also found in: Medical, Wikipedia 0.01 sec.
therapeutic index
n.
The ratio between the toxic dose and the therapeutic dose of a drug, used as a measure of the relative safety of the drug for a particular treatment.
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It has effectiveness similar to theophylline in controlling asthma with a better therapeutic margin than theophylline.
Clinical application of nonsteroidal agents by Gardenhire, Doug / FOCUS: Journal for Respiratory Care & Sleep Medicine
NASDAQ: TRGT), a clinical-stage biopharmaceutical company developing a new class of drugs known as NNR Therapeutics (TM), today announced that it has completed analysis of data from a Phase 1 multiple rising dose trial of TC-6499, a product candidate included in the GlaxoSmithKline alliance, and concluded that the results do not project a therapeutic margin sufficient to support further development of TC-6499 for neuropathic pain.
Targacept Provides Update on TC-6499 and Pain Program in ... by Business Wire
Many clinicians believe that the cromolyn-like agents and antileukotrienes are preferable to theophylline in terms of side effects and therapeutic margin.
Xanthines: the side door bronchodilators by Gardenhire, Doug / FOCUS: Journal for Respiratory Care & Sleep Medicine
 
 
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