Messenger RNA levels of toll-like receptor
9 (TLR9) (A), myeloid differentiation primary response 88 (MYD88) (B), interleukin-1 receptor-associated kinase 1 (IRAK1) (C), tumor necrosis factor receptor-associated factor 6 (TRAF6) (D), and nuclear factor B (NF-[kappa]B) (E) in peripheral blood mononuclear cells of chronic hepatitis B virus (CHB)-infected patients and healthy controls.
Title: Novel Toll-Like Receptor
Antagonists Strongly Decrease Expression of IL-23-induced and Psoriasis Profile Genes in a Mouse Model
The receptors, or sensors, on cells are called Toll-like receptors
(TLRs), and the Nobel Prize was awarded last year for discoveries that showed they initiate the swift innate immune response to infections.
They then tested the impact this variant had on retinal pigment epithelial cells in humans and in mice, including wild-type and toll-like receptor
3 knockout animals.
(TLR)2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaccharide responses.
In the new study, the scientists gave a single shot of alcohol to laboratory mice and studied the effect of blocking Toll-like receptors
, a particular element of the immune system, on the behavioural changes induced by alcohol.
Rapid and reliable genotyping for the Toll-like receptor
4 A896G polymorphism using fluorescence-labeled hybridization probes in a real-time polymerase chain reaction assay.
and her colleagues conducted a series of experiments on mice and rats to clarify the role in neuropathic pain of a cell-surface protein dubbed TLR4, short for toll-like receptor
TLR4 is a well characterized toll-like receptor
with extensive publications outlining its role as a key mediator of acute and chronic inflammation.
a clinical stage biopharmaceutical company committed to the development and commercialization of novel Toll-like receptor
8 (TLR8) immunotherapies, today announced an update on corporate and clinical activities at the company including management structure, commitment for future funding, ongoing clinical trials and future clinical development efforts.
IL-12 receptor beta 1 and Toll-like receptor
4 increase IL-1 beta- and IL-18-associated myocarditis and coxsackievirus replication.
2 functions as a pattern recognition receptor for diverse bacterial products.