Ramipril, imidapril, perindopril, enalapril, lisinopril, benazepril, fosinopril, trandolapril
, and quinapril dominate the ACEIs.
In 3717 patients who were randomized to trandolapril
or placebo as part of the Prevention of Events with Angiotensin Converting Enzyme (PEACE) trial, increased concentrations of MR-proANP were independently associated with the risk of cardiovascular death or heart failure (HR per 1 SD, 1.
The post-hoc analysis focused on a subgroup of 8,354 patients from among the 22,576 total patients enrolled in the International Verapamil SR Trandolapril
Study (INVEST), which enrolled patients aged 50 years or older with hypertension and preexisting coronary artery disease at 862 centers in 14 countries (JAMA 2003;290:2805-16).
lisinopril, moexipril, perindopril, quinapril, ramipril, trandolapril
A clinical trial of the angiotensin-convertingenzyme inhibitor trandolapril
in patients with left ventricular dysfunction after myocardial infarction.
The long-term impact of the angiotensin-converting enzyme inhibitor trandolapril
on mortality and hospital admissions in patients with left ventricular dysfunction after a myocardial infarction: follow-up to 12 years.
Camm and The Trandolapril
Cardiac Evaluation Study Group.
25-20 Moderate Trandolapril
2, 15-24 (a) 1-8 Moderate Significantly binds ACE inhibitor tissue ACE Prodrug Benazepril No Yes Captopril No No Enalapril No Yes Fosinopril No Yes Lisinopril No No Moexipril Yes Yes Perindopril Yes Yes Quinapril Yes Yes Ramipril Yes Yes Trandolapril
Yes Yes (a)Biphasic; pharmacokinetically has two peaks associated with two different half-lives.
ACE Inhibitors: benazepril, lisinopril, monopril, quinapril, ramipril, trandolapril
Some ACE inhibitors are known as "centrally-acting" because they can cross the blood-brain barrier- a specialized system of tiny blood vessels that protects the brain from harmful substances in the blood stream-that include captropril, fosinopril, perindopril, ramipril and trandolapril
In brief, the PEACE trial was a double-blind, phase III trial that randomized patients with stable CAD and preserved left ventricular function to trandolapril
11 Percentage of patients who receive the ACE inhibitor trandolapril
for the treatment of Hypertension