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trandolapril

   Also found in: Medical, Wikipedia 0.02 sec.
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Noun1.trandolapril - an ACE inhibiting drug (trade name Mavik) used in some patients after a heart attack or to treat hypertension
ACE inhibitor, angiotensin-converting enzyme inhibitor - an antihypertensive drug that blocks the formation of angiotensin II in the kidney, leading to relaxation of the arteries; promotes the excretion of salt and water by inhibiting the activity of the angiotensin converting enzyme; also used to treat congestive heart failure


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Some ACE inhibitors are known as "centrally-acting" because they can cross the blood-brain barrier- a specialized system of tiny blood vessels that protects the brain from harmful substances in the blood stream-that include captropril, fosinopril, perindopril, ramipril and trandolapril.
25-20 Moderate Trandolapril 2, 15-24 (a) 1-8 Moderate Significantly binds ACE inhibitor tissue ACE Prodrug Benazepril No Yes Captopril No No Enalapril No Yes Fosinopril No Yes Lisinopril No No Moexipril Yes Yes Perindopril Yes Yes Quinapril Yes Yes Ramipril Yes Yes Trandolapril Yes Yes (a)Biphasic; pharmacokinetically has two peaks associated with two different half-lives.
The angiotensin converting enzyme inhibitor trandolapril has neutral effect on exercise tolerance or functional class in patients with myocardial infarction and reduced left ventricular systolic function.
 
 
 
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