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trandolapril |
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Some ACE inhibitors are known as "centrally-acting" because they can cross the blood-brain barrier- a specialized system of tiny blood vessels that protects the brain from harmful substances in the blood stream-that include captropril, fosinopril, perindopril, ramipril and trandolapril. 25-20 Moderate Trandolapril 2, 15-24 (a) 1-8 Moderate Significantly binds ACE inhibitor tissue ACE Prodrug Benazepril No Yes Captopril No No Enalapril No Yes Fosinopril No Yes Lisinopril No No Moexipril Yes Yes Perindopril Yes Yes Quinapril Yes Yes Ramipril Yes Yes Trandolapril Yes Yes (a)Biphasic; pharmacokinetically has two peaks associated with two different half-lives. The angiotensin converting enzyme inhibitor trandolapril has neutral effect on exercise tolerance or functional class in patients with myocardial infarction and reduced left ventricular systolic function. |
trandolapril |
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