Integracides: Tetracyclic Triterpenoid
Inhibitors of HIV-1 Integrase Produced by Fusarium Sp.
They are classified into triterpenoid
, steroid or steroidal glycoalkoid.
The company's lead product candidate, SCY-078, is the first representative of a novel oral and IV triterpenoid
antifungal family and is in Phase 2 clinical development for the treatment of several fungal infections, including serious and life-threatening invasive fungal infections.
In addition to playing a complementary role with beta-glucans in immune system activation, triterpenoid
actions are also hepatoprotective, lipid lowering, antioxidant, anti-inflammatory, and inhibit histamine release.
Ethanol extraction of plant lead to highly oxygenated mostly polar bioactive compounds like triterpenes, triterpenoid
and glycosides (Bhat, 2005).
Ursolic acid (3beta-hydroxy-urs-12-en-28-oic acid) is a pentacyclic triterpenoid
found naturally in apples, waxy berries, rosemary, oregano, and several other plants and herbs used in medicine and the diet.
Also known as gotu kola, Centella asiatica contains triterpenoid
compounds that help stabilize soft plaque by improving the synthesis of collagen, (10-13) a component of the thick caps that hold soft plaque in place.
index was calculated to reveal the triterpenoid
composition of oak.
Profiling of triterpenoid
saponin content variation in different chemotypic accessions of Centella asiatica L.
This contribution may be due to the biocidal aspects of triterpenoid
saponins, the main component of the plant extract, which may have favoured the sanitation of the root environment, possibly acting on nematodes, which damage the root system (Ritzinger, Borges, Ledo, & Caldas, 2007), resulting in better root development than with only HS application.
Drug development company SCYNEXIS (NasdaqGM:SCYX) revealed on Wednesday the receipt of the orphan drug designation from the US Food and Drug Administration (FDA) has for the novel triterpenoid
broad-spectrum antifungal agent, SCY-078, for the treatment of invasive Aspergillus infections.
In addition, the triterpenoid
compounds isolated from leaves of Diospyros kaki also have effect of suppressing N-formyl-methionyl-leucylphenylalanine (fMLP)-induced superoxide generation (Chen et al.