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tumor suppressor gene |
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Lead researcher Dr Paul Edwards said: "NRG1 could be the most important tumour suppressor gene discovery in the last 20 years as it gives us vital information about a new mechanism that causes breast cancer. During the studies, a form of organic selenium found naturally in garlic and Brazil nuts was converted in cancer cells to metabolites that acted as "HDAC inhibitors" - a promising field of research in which silenced tumour suppressor genes are re-activated, triggering cancer cell death. However, the role of tumour suppressor gene mutations is indicated by their association with Li-Fraumeni syndrome, which is characterized by inactivating germline mutations of the TP53 gene, gives some insight into the origins of these tumours (1, 3). |
Tumour suppressor gene |
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