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tumor suppressor gene
(redirected from Tumour suppressor gene)

   Also found in: Medical, Encyclopedia, Wikipedia 0.01 sec.
tumor suppressor gene
A gene that suppresses cellular proliferation. When inherited in a mutated state in which it is no longer suppressive, it is associated with the development of various cancers, including most familial cancers.
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.tumor suppressor gene - a suppressor gene that blocks unscheduled cell division
suppresser gene, suppressor gene, suppresser, suppressor - a gene that suppresses the phenotypic expression of another gene (especially of a mutant gene)


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Lead researcher Dr Paul Edwards said: "NRG1 could be the most important tumour suppressor gene discovery in the last 20 years as it gives us vital information about a new mechanism that causes breast cancer.
During the studies, a form of organic selenium found naturally in garlic and Brazil nuts was converted in cancer cells to metabolites that acted as "HDAC inhibitors" - a promising field of research in which silenced tumour suppressor genes are re-activated, triggering cancer cell death.
However, the role of tumour suppressor gene mutations is indicated by their association with Li-Fraumeni syndrome, which is characterized by inactivating germline mutations of the TP53 gene, gives some insight into the origins of these tumours (1, 3).
 
 
 
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