factor VIII

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factor VIII

n.
A protein substance in blood plasma that is an essential part of the blood-clotting process. Most cases of hemophilia are caused by a genetic defect that leads to a deficiency of this factor. Also called antihemophilic factor.

factor VIII

n
(Biochemistry) a protein that participates in the clotting of blood. It is extracted from donated serum and used in the treatment of the commonest type of haemophilia, in which it is absent

factor VIII


n.
an enzyme of blood plasma that is essential to normal blood clotting: lacking or deficient in hemophiliacs.
[1960–65]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.factor VIII - a coagulation factor (trade name Hemofil) whose absence is associated with hemophilia Afactor VIII - a coagulation factor (trade name Hemofil) whose absence is associated with hemophilia A
clotting factor, coagulation factor - any of the factors in the blood whose actions are essential for blood coagulation
References in periodicals archive ?
von Willebrand factor cleaving protease (ADAMTS-13) and ADAMTS-13 neutralizing autoantibodies in 100 patients with thrombotic thrombocytopenic purpura.
Venous blood samples were taken and screened for the hemoglobin level (Hb), platelet count, PT, aPTT and von Willebrand Factor Antigen (vWF:Ag) in addition to BT at the AFIP.
Von Willebrand factor antigen (VWF:Ag) concentrations were determined with an in-house ELISA assay, using polyclonal rabbit anti-human VWF antibodies (DakoCytomation) for capturing and detecting (23).
Measures of HNPs 1-3 by both methods correlated well, and the researchers concluded that HNPs 1-3 likely inhibit ADAMTS13 activity by binding to the central A2 domain of von Willebrand factor and physically blocking ADAMTS13 binding.
Validation of a new panel of automated chemiluminescence assays for von Willebrand factor antigen and activity in the screening for von Willebrand Disease.
8] This modality of treatment depletes the circulating antibodies against ADAMTS13 and the very high molecular weight von Willebrand factor multimers.
Men and women are equally affected by VWD, which is caused by a deficiency or defect in von Willebrand factor, a critical protein for blood clotting.
Desmopressin or 1-deamino-8-D-arginine vasopressin (DDAVP) can increase the serum levels of von Willebrand factor (vWF) and coagulation factor VIII, so it can enhance platelet (PLT) function and improve coagulation.
Relationship between ABO and Secretor genotype with plasma levels of factor VIII and von Willebrand factor in thrombosis patients and control individuals.
For the Subcommittee on von Willebrand Factor of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis".
Von Willebrand disease (vWD) is the most common inherited bleeding disorder in humans, occurring in about 1% of women and caused by a deficiency or abnormality in the von Willebrand factor (vWF) (1).