factor VIII

(redirected from Von Willebrand factor)
Also found in: Thesaurus, Medical, Acronyms, Encyclopedia, Wikipedia.

factor VIII

n.
A protein substance in blood plasma that is an essential part of the blood-clotting process. Most cases of hemophilia are caused by a genetic defect that leads to a deficiency of this factor. Also called antihemophilic factor.

factor VIII

n
(Biochemistry) a protein that participates in the clotting of blood. It is extracted from donated serum and used in the treatment of the commonest type of haemophilia, in which it is absent

factor VIII


n.
an enzyme of blood plasma that is essential to normal blood clotting: lacking or deficient in hemophiliacs.
[1960–65]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.factor VIII - a coagulation factor (trade name Hemofil) whose absence is associated with hemophilia Afactor VIII - a coagulation factor (trade name Hemofil) whose absence is associated with hemophilia A
clotting factor, coagulation factor - any of the factors in the blood whose actions are essential for blood coagulation
References in periodicals archive ?
Von Willebrand factor collagen-binding (activity) assay in the diagnosis of von Willebrand disease: a 15-year journey.
Elevated von Willebrand factor is known to be associated with endothelial damage and dysfunction, said Dr.
ZLB Behring's von Willebrand Factor (VWF) / factor VIII concentrate Humate-P(R) (marketed in Europe as Haemate(R) P) is a factor replacement therapy with more than 20 years of demonstrated safety and efficacy around the world.
Recombinant von Willebrand factor (rVWF) may be safe and well tolerated in patients with type 3 and severe type 1 von Willebrand disease, according to interim data from a Phase 1 multicenter, international clinical study presented today at the 52nd Annual Meeting of the American Society of Hematology.
Specific treatments may include desmopressin acetate to release stored von Willebrand factor, or von Willebrand factor replacement therapy, where required, with Humate-P(R), Antihemophilic Factor/von Willebrand Factor Complex (Human), the only product licensed by the FDA for the treatment of von Willebrand disease.
Real-time analysis of shear-dependent thrombus formation and its blockade by inhibitors of von Willebrand factor binding to platelets.
In the second part of his talk, Dr Kessler presented an improved method for von Willebrand factor level monitoring in VWD patients using a new assay that provides increased sensitivity and optimized level of detection, which is especially important for severe cases of VWD with strongly reduced levels of VWF (Type 3).
July 11, 2012 /PRNewswire/ -- Findings of a first-of-its-kind study of women with von Willebrand disease (VWD) show that current postpartum treatment strategies do not increase levels of von Willebrand factor (VWF) to normal range or even to the levels of women with milder, untreated VWD.
ARC1779 is designed to inhibit the function of a protein called von Willebrand Factor, or VWF, which, when activated, is responsible for the adhesion, activation and aggregation of platelets by a mechanism distinct from those targeted by marketed anti-platelet therapies such as aspirin, clopidogrel and Gp IIb/IIIa inhibitors.
Caused when von Willebrand factor, a protein in the blood that is necessary for clotting, is either missing or not working properly, VWD affects men and women equally.
TMA is caused by failure of regulation of the activity of the protein known as von Willebrand Factor, or vWF, which under normal conditions plays a key role in protecting the body from bleeding.
Lot 7 - Coagulation Factor VIII von Willebrand factor plasma + 500 IU / fl.