Lean phenotype and resistance to diet-induced obesity in vitamin D receptor knockout mice correlates with induction of uncoupling protein-1 in white adipose tissue
Therefore, the adipose organ comprises white adipose tissue
(WAT), the main energy storage allowing animals to survive for longer periods without meals, and brown adipose tissue (BAT), a key site of heat production (thermogenesis) in mammals, essential for the survival in cold environments and in hibernators, defending core body temperature.
Soon after blood harvesting, the white adipose tissue
of each animal was surgically excised and weighed.
showed that irisin, a newly identified myokine, induces the browning of subcutaneous white adipose tissue
by increasing the uncoupling protein-l (UCP1), with subsequent the stimulation of oxygen consumption and thermogenesis (l, 17).
In male wt mice, the largest increases in CXCL chemokines expression in response to TCDD were observed in epididymal white adipose tissue
GSE44372 included six samples obtained from rat visceral pancreatic white adipose tissues
from three obese, and three nonobese animal subjects.
This is a proof-of-concept approach for selectively targeting the white adipose tissue
and 'browning it' to allow the body to burn fat.
It is secreted by a variety of tissues, mainly by liver and white adipose tissues
(WAT), and exists in either native (full-length) form with molecular mass of ~50 kDa (Mandard et al.
Beattie, "Physiological role of adipose tissue: white adipose tissue
as an endocrine and secretory organ," Proceedings of the Nutrition Society, vol.
In addition, the precursor cells of white adipose tissue
can be modified with different factors to give rise to adipose tissue that is more energetically active [24, 25], Table 1 Multiple factors may modulate the process of differentiation of beige adipocytes from adipocyte precursor cells.
2) p107 is strictly expressed in the stem cell compartment of white adipose tissue
and completely absent in brown adipose tissue.
A blend from Mediterranean citrus fruit and a South American seed has been shown to increase hormone-sensitive lipase activity in white adipose tissue
cells, restoring their ability to free up--and burn off--their stores of excess energy.