Several drugs are in proof-of-principle or efficacy/safety stages in humans because of what we have learned over the past three decades about the isoforms of the enzymes relevant to the metabolism of xenobiotics
The cytochrome P450 superfamily includes numerous proteins able to metabolize xenobiotics
A sampling of topics: mechanism of action and cancer therapeutic potential of retinoids; transcriptional regulation of hepatic genes by insulin and glucose; PPARs in atherosclerosis; gene variants and obesity; gene polymorphisms, nutrition, and the inflammatory response; taste receptors and their variants; and cancer and gene variants in enzymes metabolizing dietary xenobiotics
The development of methods for assessing the in vivo oestrogen-like effects of xenobiotics
in CD-1 mice.
Those on natural organics and xenobiotics
cover soil and organic wastes, the dynamics of extractable and bound residues, and geochemical studies of chemical concentrations in peats in Poland.
These data can be combined with pharmacological models to present a true systems biology approach to quantifying risks from exposure to xenobiotics
such as TCDD, suggest the authors.
He begins by describing the theories of evolution about the first cells and their signaling molecules, then on to signaling systems into true nervous systems, neurohormone/receptor structures, the involvement of osmoregulation, metabolism, and energy, growth and development, biological rhythms, reproduction, behavior, learning and memory, and xenobiotics
and hormone mimics.
Thus, exposure to PCBs may blunt the human xenobiotic
response, inhibiting the detoxification of steroids, bioactive dietary compounds, and xenobiotics
normally mediated by SXR.
American researchers in toxicology and other fields provide background on the basics of the technique for understanding the physical, chemical, and biological properties that determine the absorption, distribution, metabolism, and elimination of xenobiotics