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Specifically, men with haplogroup I were shown to have decreased expression of 2 genes: the ubiquitously transcribed tetratricopeptide repeat, Y-linked gene (UTY) and protein kinase, Y-linked, pseudogene (PRKY) in macrophages.
The findings suggest that because these Y-linked genes are active across the body, they may actually be contributing to differences in disease susceptibility and severity observed between men and women.
If X-linked drive alleles are normally suppressed by conspecific Y-linked genes, these suppressors are missing in the hybrid males, who should therefore show meiotic drive.