ZDV


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ZDV

abbr.
zidovudine
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.ZDV - an antiviral drug (trade name Retrovir) used in the treatment of AIDSZDV - an antiviral drug (trade name Retrovir) used in the treatment of AIDS; adverse side effects include liver damage and suppression of the bone marrow
NRTI, nucleoside reverse transcriptase inhibitor - an antiviral drug used against HIV; is incorporated into the DNA of the virus and stops the building process; results in incomplete DNA that cannot create a new virus; often used in combination with other drugs
References in periodicals archive ?
09) 10,000-50,000 - - 50,000-100,000 - - Number of regimens - - Mono ZDV 2.
The Department of Health and Human Services (DHHS) for the US currently recommends that at least 3 doses of nevirapine within the first 7 days of life be administered, in addition to ZDV therapy as prophylaxis during high-risk perinatal exposure when maternal HIV viral load is or is assumed to be more than 1,000 copies/mL.
Because there is clearly a need for more effective drugs with fewer side effects for FIV treatment the authors evaluated a compound related to ZDV, fozivudine (FZD), in a controlled experimental trial ("Fozivudine tidoxil as single-agent therapy decreases plasma and cell-associated viremia during acute feline immunodeficiency virus infection," Journal of Veterinary Internal Medicine, 2011).
In the RAVE study [37], patients who had been taking ZDV showed better recovery of limb fat when they switched to ABC.
However, PLSCS is recommended for all women taking ZDV monotherapy, women on combination therapy with detectable viraemia and women with HIV/HCV co-infection.
In February 1994 the Pediatric AIDS Clinical Trials Group (PACTG) 076 trial demonstrated a breakthrough prevention intervention with a 67% reduction in perinatal HIV transmission by using a three-part regimen consisting of administration of ZDV to the mother during pregnancy, intravenous ZDV during labor, and ZDV to the infant for 6 weeks (3).
Age Sex drugs received start of ART 2-29 46 F 3TC, ZDV, EFV 33 2-44 49 F 3TC, ZDV, EFV 10 2-47 42 M 3TC, ZDV, IDV 10 2-59 36 F 3TC, ZDV, EFV, 52 IDV 2-66 36 M 3TC, ZDV, d4T, 21 ddl, EFV 2-70 30 M d4T, ddl, EFV 6 2-75 37 F 3TC, d4T, IDV 9 2-76 34 M 3TC, d4T, EFV 10 2-84 51 M 3TC, ZDV, d4T, 48 ddl, NFV 2-91 44 M 3TC, d4T, EFV, 6 IDV 2-98 32 F d4T, ddl, IDV 7 22-2 42 M 3TC, ZDV, EFV 14 22-9 33 F 3TC, ZDV, d4T, 31 ddl, EFV, IDV 22-25 30 F 3TC, ZDV, EFV, 18 IDV 22-31 42 M 3TC, d4T, IDV 8 22-33 41 F 3TC, ZDV, IDV 18 22-35 58 M 3TC, ZDV, IDV 17 22-47A 48 F 3TC, ZDV, EFV, 45 IDV 22-50 32 M 3TC, d4T, NVP 6 22-57 53 M 3TC, ZDV, EFV 7 221-75 50 F 3TC, ZDV, d4T, 29 ddl, EFV, IDV Patient no.
Este comprende la adecuada decision de la via del parto, profilaxis con ZDV y suministro de leche de formula.
Hepatic failure was reported in six patients on NVP, seven on ZDV, five on 3TC, and five on d4T.
Both ZDV-sensitive and ZDV-resistant clinical HIV-1 isolates were >4 log more sensitive to PAP than to ZDV (Zarling et al.
However, she may be HIV-positive, and it will be in the interest of the unborn child that she receives ZDV treatment in an early stage of pregnancy.
In one study, 6 months of ZDV monotherapy led to initial improvement in CD4 count but after treatment was discontinued, CD4 decline was more rapid in the ZDV-treated group than in the placebo ann.