Constantly evolving viral genome induces resistance against current anti- influenza drug regimens comprising newly developed drugs such Tamiflu, zanamivir
, amantadine, etc.
The dosages for treatment with oseltamivir and zanamivir
are provided in Table 1.
Although there was an I314V mutation in the NA of the 3 viruses, other mutations that encode oseltamivir and zanamivir
resistance were not detected (9).
All the patients were treated with oseltamivir, and zanamivir
was switched to oseltamivir in 1 patient.
Dual treatment with oseltamivir and zanamivir
was used when resistant virus was suspected or confirmed.
So basically all that physicians had available early on were the oral neuraminidase inhibitor oseltamivir (Tamiflu) and the inhalation-only formulation of zanamivir
(Relenza), another neuraminidase inhibitor.
Prime compared the use of influenza drugs oseltamivir (Tamiflu), zanamivir
(Relenza), and rimantadine (Flumadine) during this season to typical flu seasons.
Besides oseltamivir, other neuraminidase inhibitors are zanamivir
(Relenza), which is inhaled, and the intravenously administered investigational drug peramivir.
The antiviral medications oseltamivir (Tamiflu[TM], Roche Laboratories) and zanamivir
(Relenza[TM], GlaxoSmithKline) can reduce the severity and duration of and complications from H1N1 and are recommended for individuals with suspected or confirmed influenza requiring hospitalization.
drugs, oseltamivir or zanamivir
, for patients who meet treatment criteria,
Treatment of swine flu is based on antiviral drugs such as Oseltamivir and Zanamivir
, a drug for the treatment of flu.
The study showed that there was an overall reduction in the median time to symptom alleviation in healthy adults by 0A[cedilla]57 days (95% CI -1A[cedilla]07 to -0A[cedilla]08; p=0A[cedilla]02; 2701 individuals) with Zanamivir
, and 0A[cedilla]55 days (95% CI -0A[cedilla]96 to -0A[cedilla]14; p=0A[cedilla]008; 1410 individuals) with Oseltamivir.