zoledronic acid

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zoledronic acid, zoledronate

n ácido zoledrónico, zoledronato (esp. Esp)
References in periodicals archive ?
4) The analysis involved five trials of oral alendronate and three trials of intravenous zoledronate (zoledronic acid).
Positive effects of zoledronate on skeletal-related events in patients with renal cell cancer and bone metastases.
The patient was hospitalised for further management, and palliative radiotherapy (800 cGy, single fraction) was given to the involved vertebra along with monthly intravenous injections of zoledronate 4 mg.
The efficacy of clodronate, pamidronate, and zoledronate in preventing bone lesions has been investigated in several randomised trials, while for ibandronate limited data from randomised trials are available (32).
Studies evaluating the effects of pamidronate and zoledronate on skeletal metastases of thyroid cancer have been reported Rosen et al.
To date, alendronate, pamidronate, and zoledronate seem to be effective in increasing BMD and normalizing bone turnover (3,5,16).
Zoledronic acid (INN) or zoledronate (sold by Novartis as Zometa, Zomera, Aclasta and Reclast) is a bisphosphonate.
Risedronate and Zoledronate potently block isoprenoid biosynthesis, but are unable to get across the membrane of red blood cells to get to the parasite.
BOSTON--An annual dose of zoledronate that has been reduced by 50% or even 80% appears to be as effective as the recommended 5-mg dose in increasing bone mineral density and decreasing markers of bone turnover in osteopenic postmenopausal women, according to Dr.
Because of subsequent unavailability of pamidronate, three patients received other bisphosphonates (1 patient received intravenous zoledronate, once yearly, 1 patient received oral alendronate daily and another patient received combined intravenous and intralesional zoledronate which is still experimental)11.
The use and efficacy of these agents (intravenously administered pamidronate, zoledronate, ibandronate), in concurrence with antineoplastic chemotherapy, has been well documented in the treatment of bone pain, moderate-to-severe hypercalcemia, and other skeletal complications associated with such malignancies as metastatic breast cancer and multiple myeloma.