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Related to Zymogens: Isoenzymes, Isozymes




(Biochemistry) biochem any of a group of compounds that are inactive precursors of enzymes and are activated by a kinase


(ˈzaɪ mə dʒən, -ˌdʒɛn)

any of various enzyme precursor molecules that may change into an enzyme as a result of catalytic change. Also called proenzyme.
[< German (1875); see zymo-, -gen]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.zymogen - any of a group of compounds that are inactive precursors of enzymes and require some change (such as the hydrolysis of a fragment that masks an active enzyme) to become active
organic compound - any compound of carbon and another element or a radical
References in periodicals archive ?
Apoptosis is usually executed by caspases, a family of highly conserved aspartate-specific cysteine proteases which are constitutively expressed as zymogens (Li and Yuan 2008).
Trypsinogen, like all other zymogens, is packaged in zymogen granules, which further retard trypsinogen activation.
In detail, enterokinase was added to homogenate to activate pancreatic zymogens before determination of pancreatic trypsin and protease.
the activation of some zymogens of the coagulation cascade or the maturation of insulin.
a) Zymogen IA is a common precursor for gastricsin and human pepsin, and (b) Zymogen IA consists of two zymogens, pepsinogen and a zymogen for gastric sin.
PCD promoting signals have been suggested to induce inactive zymogens to active proteases, and trigger irreversible proteolysis cascade leading to cell death (Stephenson & Rubinstein, 1998).
The activity levels of each of the 4 vitamin K-dependent zymogens (II, VII, IX, and X) decreased as the INR level increased.
In the family, Caspase-3 in its inactive zymogens, pro-caspase-3 is a remarkable protein as the enzyme shows a large substrate diversity, as a variety of proteins have been cleaved in cell maintenance.