More specifically, 9 patients had cholangiocarcinoma, 9 had gallbladder cancer and 2 had cancer of the
Ampulla of Vater. Patients received a median of 2 prior systemic regimens before entering this trial.
Malignant gastrointestinal stromal tumor of the
ampulla of Vater presenting with obstructive jaundice.
000001, the summary random effects were significant in 35 meta-analyses 31 of these found increased risk with adiposity of esophageal adenocarcinoma, multiple myeloma, and cancers of the colon, rectum, liver, biliary tract system (cancers of gallbladder, extrahepatic bile duct, and
ampulla of Vater), pancreas, postmenopausal breast, endometrium, and kidney.
Other tumor sites included the rectum, the pancreas, the
ampulla of Vater, the sigmoid colon, and the ductus choledochus.
Ampullary cancer is a cancer that arises from the
ampulla of Vater, which is where the bile duct and pancreatic duct come together and empty into the small intestine.
Intraductal papillary component, dilatation of the downstream pancreatic duct, or spillage of mucin from the
ampulla of Vater at endoscopic retrograde cholangiopancreatography are the features of IPMNs, but not of colloid carcinomas (11).
Biliary obstructions in these patients were pancreatic cancer (n = 72), cholangiocarcinoma (n = 40), malignant gastric carcinoma (n = 21), cancer of the
ampulla of Vater (n =10), gallbladder carcinoma (n = 7), colon cancer metastasis (n = 3), lung cancer metastasis (n = 2), and ovary cancer metastasis (n = 1).
Endoscopic ultrasonography was performed to investigate other causes, but the
ampulla of Vater could not be observed due to technical difficulty.
One patient was converted to laparotomy with continued endoscopy to locate the
ampulla of Vater, which was successful.
She underwent a computed tomography (CT) scan and an ultrasound, both of which showed a grossly distended and thickened gallbladder containing numerous gallstones, with a distended bile duct and inflammatory changes extending to the
ampulla of Vater.
Treatment of Carcinoma of the
Ampulla of Vater. Ann Surg 1935; 102: 763-79.