Everyone who entered the trial had a viral load above 1000 copies when the study began, and no one had taken Kaletra, Prezista, Aptivus (tipranavir), or Fuzeon (enfuvirtide) before.
New second-generation PIs darunavir (Prezista; Tibotec) and tipranavir (Aptivus; Boeringer-Ingelheim) both require boosting with ritonavir, but require a large number of mutations before they lose efficacy.
McCallister held positions at Boehringer Ingelheim Pharmaceuticals (BI), leading the international clinical development program and regulatory review process for its anti-HIV protease inhibitor, tipranivir (APTIVUS).
Reports of fatal and nonfatal intracranial hemorrhage among HIV-1 infected patients taking Aptivus (tipranavir) in combination antiretroviral therapy have prompted the manufacturer to issue new safety information.
Reports of fatal and nonfatal intracraial hemorrhage among HIV-1 infected patients taking Aptivus (tipranavir) in combination antiretroviral therapy have prompted the manufacturer to issue new safety information.
The lower price could well be in the company's financial interest, by allowing first-line use if the drug proves suitable--especially important now that its rival Aptivus (tipranavir) does not seem to be working well as a first-line treatment, with a clinical trial stopped because of performance that appeared slightly inferior to a good standard treatment based on Kaletra.
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