CD4

(sē′dē-fôr′)

A glycoprotein that is found on the surface of T cells, especially helper T cells, and functions as a receptor in activation of the cells. In humans, HIV gains entry to helper T cells by binding to the CD4 receptor.

[c(luster of) d(ifferentiation antigen) 4.]

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

CD4

a protein on the surface of T cells and other cells, functioning as a receptor for the AIDS virus antigen.

[1980–85; c(luster of) d(ifferentiation) 4]

ThesaurusAntonymsRelated WordsSynonymsLegend:

Noun

CD4 - a glycoprotein that is found primarily on the surface of helper T cells; "CD4 is a receptor for HIV in humans"

cluster of differentiation 4

glycoprotein - a conjugated protein having a carbohydrate component

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References in periodicals archive

Co-trimoxazole (CTX) prophylaxis is recommended for adults (including pregnant women) with severe or advanced HIV clinical disease (WHO stage 3 or 4) and/or with a CD4 count <350 cells/[micro]l.

Twelve steps to CD4 testing--Part III: Management of opportunistic infections

Altering CD4 gene methylation status, the expression was changed which related to resistance to virus infection [18] and inflammatory diseases [19].

Correlation analyses of CpG island methylation of cluster of differentiation 4 protein with gene expression and T lymphocyte subpopulation traits

Studies of nonlung cancers in people with HIV suggest that prolonged periods at a low CD4 count heighten cancer risk.

Big 3 lung cancer risk factors with HIV: smoking, low CD4s, lung infection

This implies that the association between the CD4 cell count and hypertension could be different across the various BMI categories.

Association between CD4 Cell Count and Blood Pressure and Its Variation with Body Mass Index Categories in HIV-Infected Patients

Expression profiling of PD-1, CK7, CK20, Ki-67, E-Cad, and CD4 was assessed by IHC on 4 [micro]m thick FFPE sections.

Expression of PD-1 on [CD4.sup.+] Tumor-Infiltrating Lymphocytes in Tumor Microenvironment Associated with Pathological Characteristics of Breast Cancer

Widespread and routine use of CD4 counts and plasma viral load in the management of HIV has not been possible in resource limited settings.

EVALUATION OF TOTAL LYMPHOCYTE COUNT, BODY MASS INDEX, HAEMOGLOBIN AND ALBUMIN LEVELS AS LOW COST SURROGATE MARKERS FOR CD4 COUNTS IN ASSESSING DISEASE PROGRESSION IN HIV/AIDS- A DESCRIPTIVE STUDY

During the period 2004-2015, the NHLS provided >32 million CD4 tests in support of the CCMT programme.

Analysis of HIV disease burden by calculating the percentages of patients with CD4 counts <100 cells/[micro]l across 52 districts reveals hot spots for intensified commitment to programmatic support

Median CD4 count and viral load collected closest to NTM diagnosis were 10 cells/[mm.sup.3] and 131,446 copies/mL, respectively.

Disseminated nontuberculous mycobacteria in HIV-infected patients, Oregon, USA, 2007-2012

In recent times one of the greatest challenges in the management and care of HIV in poor resource settings has been the evaluation of CD4 count measurement; a parameter which is seen as a traditional biomarker for predicting the progression and monitoring treatment response to highly active antiretroviral therapy (HAART) [7].

Body Mass Index, Haemoglobin, and Total Lymphocyte Count as a Surrogate for CD4 Count in Resource Limited Settings

Lo descrito favorece la caracteristica fenotipica de esta entidad, caracterizada por un leve descenso de linfocitos T CD8+, por la disminucion de la relacion CD4:CD8 y porque los linfocitos B pueden estar disminuidos en algunos pacientes; sin embargo, en todos se encuentran concentraciones normales de inmunoglobulinas [2].

Idiopathic T CD4+ lymphocytopenia. Case report/Linfocitopenia T CD4+ idiopatica: reporte de caso