CMV - any of a group of herpes viruses that enlarge epithelial cells and can cause birth defects; can affect humans with impaired immunological systems
Worldwide incidence of congenital CMV infection is estimated at 0.2% to 2.5% of all live births, and incidence within the United States is estimated at 0.64%.
Loss of this balance--as seen in association with disease or drug treatment--can lead to uncontrolled viral replication resulting in CMV reactivation and disease.
Active CMV infection correlates with a higher risk of other infections, post-transplant lymphoma, organ rejection, and overall morbidity and mortality.
Public health agency The US Food and Drug Administration announced on Friday that it has approved the marketing of a new diagnostic test, the Alethia CMV Assay Test System, to aid in detecting the cytomegalovirus (CMV) herpes virus in newborns less than 21 days of age through the de novo premarket review pathway.
The usual manifestations of overt CMV infection at birth are hepatosplenomegaly, jaundice, thrombocytopenia and various congenital malformations, especially those involving the central nervous system.
"Subclinical CMV infection alters the immune system and the gut microbiota in the host and that impacts how we respond to vaccines, environmental stimuli, and pathogens.
All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.