(Biochemistry) a crystalline insoluble acid present in bile: used as an emulsifying agent and an intermediate in the synthesis of organic compounds. Formula: C24H40O5
[32] proposed that cholic acid, the main free bile acid produced by BSH activity in the intestine, could accumulate inside the bacterial cells when the bacteria were energised.
The serum cholesterol (total, free, esterified, low density lipoprotein (LDL) and oxidized LDL) levels of rats fed a diet containing, by weight, 1% cholesterol and 0.5% cholic acid increased, as compared with those of rats fed a normal diet.
Ceragenins, Cationic Steroid Antibiotics (CSA), which are synthetic cholic acid derivatives, have the same mechanism of action as natural AMPs and mimic the activities of AMPs (Lai et al.
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