COX-1

(kŏks′wŭn′)

One of two isoenzymes that catalyze the conversion of arachidonic acid into prostaglandins. It is present in cells throughout the body and is inhibited by NSAIDs.

[c(yclo)ox(ygenase).]

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

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Noun

Cox-1 - an enzyme that regulates prostaglandins that are important for the health of the stomach lining and kidneys; "an unfortunate side effect of NSAIDs is that they block Cox-1"

cyclooxygenase-1

Cox, cyclooxygenase - either of two related enzymes that control the production of prostaglandins and are blocked by aspirin

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References in periodicals archive

COX-1 is present in most tissues and helps maintain the normal lining of the stomach as well as kidney and platelet function.

Celecoxib scores ok on cardiac safety: a three-drug, 10-year trial found it equivalent, or "noninferior," to ibuprofen and naproxen

COX-1 and COX-2, although they catalyze the same reaction but their properties are markedly dissimilar4.

EFFECTS OF DIFFERENT WARFARIN DOSES ON IL-6 AND COX-2 LEVELS

The VTE risks weren't as significant among people who use COX-1 inhibitors, such as aspirin.

NSAIDs may raise risk of blood clots developing in deep veins: COX-2 inhibitors are associated with venous thromboembolisms, but experts say use of the painkillers should be looked at on a case-by-case basis

NSAIDs work by inhibiting cyclooxygenase, COX-1 and COX-2, enzymes, which cause inflammation.

Herbal coxibs: the future of pain relief

The COX-1 enzymes have been shown to play a protective role, whereas COX-2 enzymes have been associated with inflammation and pain.

Optimizing NSAID management

Besides alcohol, platelet aggregation could be decreased by the inhibition of cyclooxygenase-1 (COX-1) activity by phenolic compounds present in wine, such as resveratrol [5].

Impact of wines and wine constituents on cyclooxygenase-1, cyclooxygenase-2, and 5-lipoxygenase catalytic activity

The former "housekeeping" functions are attributed to the first of two established COX isoforms, the constitutively expressed COX-1, while the inflammatory response is associated largely with the inducible isoform, COX-2.

Binding energy calculation of Patchouli alcohol isomer cyclooxygenase complexes suggested as COX-1/COX-2 selective inhibitor

As enzimas COX sao encontradas em isoformas diferentes e sao codificadas por dois genes diferentes, sendo a COX-1 e a COX-3 codificadas pelo gene 1 da COX e a COX-2 codificada pelo gene 2.

The sale's evaluation of drugs partially selectives to COX-2/Avaliacao da dispensacao de farmacos parcialmente seletivos para COX-2

Two isoforms are recognized: constitutive COX-1 and inducible COX-2.

Alteration of renal cyclooxygenase expression due to partial unilateral ureteral obstruction in neonatal

Therefore, there is a need to define novel, nontoxic dietary constituents with proven chemopreventive effects through other pathways that also possess COX-2 but not COX-1 inhibitory activity.

Green tea constituent epigallocatechin-3-gallate selectively inhibits COX-2 without affecting COX-1 expression in human prostate carcinoma cells

The other, COX-1, works in platelets-cells in the blood that sticks together in the first stages of clotting.

How pain medication Vioxx ups heart disease risk