Belgium-based Janssen Pharmaceutical has announced the phase three trial results for HIV drug SYMTUZA (darunavir 800mg, cobicistat 150mg, emtricitabine 200mg and tenofovir alafenamide 10mg D/C/F/TAF), it was reported on Friday.
PIs, primarily darunavir (DRV), together with a pharmacokinetic enhancer (cobicistat [c] or ritonavir [r]), are recommended for HIV-infected individuals with drug-resistant virus and may be considered for those who are poorly adherent to medication.
In DRIVE-FORWARD, PIFELTRO demonstrated sustained viral suppression through 48 weeks, meeting its primary endpoint of non-inferior efficacy compared to darunavir + ritonavir, each in combination with FTC/TDF or abacavir (ABC)/3TC.
He was started on ethambutol, levofloxacin, and rifampin for his MAC infection and subsequently highly active antiretroviral therapy (HAART) with ritonavir, darunavir, lamivudine, and efavirenz.
Once-daily dolutegravir versus darunavir plus ritonavir in antiretroviral-naive adults with HIV-1 infection (FLAMINGO): 48 week results from the randomised open-label phase 3b study.
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