A topically applied cream containing 5% vitamin C and its excipient were tested on healthy female volunteers presenting with photoaged skin on their low-neck and arms in view to evaluate efficacy and safety of such treatment.
The method is comprised of heating and melting a hydrophobic excipient and adding an antiseptic product with the melted excipient to form a liquid mixture.
The excipients involved in the active drug formulation also have a bearing because increasing the individual dose of the drug--from twice-daily to once-daily dosing--will increase the amount of excipient to which the patient is exposed.
The reduction of 5% in these values is indicative of drug degradation, and consequently, chemical incompatibility between the drug and the excipient [22].
We hypothesized that if amorphous excipients are added to a solid dispersion containing amorphous APIs then the probability of recrystallization of APIs will be arrested to a certain extent due to competition between the APIs and excipient.
The new company, which will be led by Kayon Partners principals Stephen Garrow and David Vogel, will work with the UMASS tech transfer team and with established companies in the food and drug industries, to custom-develop excipient foods, which can be used along with a variety of drugs and vitamins.
Frequent physical audits of excipients manufacturing facilities by officials from regulatory agencies lead to the imposition of substantial operating cost burdens on excipient manufacturers, thus hampering revenue growth for excipients over the forecast period.
Eudragit FL 30 D-55 leverages Evonik's new, proprietary AEMP technology (Advanced Excipient Manufacturing Process) to combine the respective benefits of two well-established and monographed polymers including Eudragit L 30 D-55, said a statement from the company.
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