factor X

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Noun1.factor X - coagulation factor that is converted to an enzyme that converts prothrombin to thrombin in a reaction that depends on calcium ions and other coagulation factors
prothrombinase
clotting factor, coagulation factor - any of the factors in the blood whose actions are essential for blood coagulation
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References in periodicals archive
RIVAROXABAN/APIXABAN/EDOXABAN interfere with factor Xa enzyme, which is involved in thrombin production
Updated Afib Guidelines Favor Newer Bloodthinners: Direct anticoagulants are highly effective and don't require as much monitoring as warfarin
United States-based Portola Pharmaceuticals has received approval from the US Food and Drug Administration (FDA) for the company's Prior Approval Supplement for the manufacturing process of second generation Andexxa [coagulation factor Xa (recombinant), inactivated-zhzo], it was reported yesterday.
US FDA approves Portola Pharmaceuticals' second generation Andexxa manufacturing process
Summary: The oral factor Xa inhibitor rivaroxaban has shown a favorable wellbeing and efficacy profile as compared to the well known anticoagulant drug warfarin for the prevention and treatment of thromboembolic disorders.
Reversal Agents for Oral Anticoagulant Rivaroxaban
Similarly, rivaroxaban, apixaban, edoxaban, and betrixaban target a different key enzyme in the cascade, factor Xa. For those confused by the generic DOAC names: for the DOACs directed against factor Xa, "xa" is included in the name of the drug, which is "banning" the activity of factor Xa.
Current anticoagulation monitoring and measurement practices
As a direct result of this, a new generation of oral anticoagulants has been developed to treat and prevent thromboembolic disorders, the direct thrombin inhibitors and the factor Xa inhibitors.
Antiplatelets & Anticoagulation Drugs: Dental Implications
(1) Based upon animal studies, ex vivo trials, and trials in healthy human volunteers, it appears that 4F-PCC may have similar efficacy in correcting laboratory measurements of coagulopathy associated with the factor Xa inhibitors apixaban and rivaroxaban.
Comparison of outcomes in patients with intracranial hemorrhage on factor Xa inhibitors versus vitamin K antagonists treated with 4-factor prothrombin complex concentrate
Rivaroxaban is a direct, antithrombin-independent factor Xa inhibitor, which inhibits not only free factor Xa, but also clot-bound factor Xa and the prothrombinase complex.
Rivaroxaban Causes Missed Diagnosis of Protein S Deficiency but Not of Activated Protein C Resistance (Factor V Leiden)
DOACs fall into 2 categories--factor IIa (thrombin) inhibitor (dabigatran) and factor Xa inhibitors (rivaroxaban, apixaban, edoxaban, and betrixaban).
Reversal Strategies for Intracranial Hemorrhage Related to Direct Oral Anticoagulant Medications
Andexanet alfa, a recombinant modified human factor Xa protein, is an antidote recently approved by the United States Food and Drug Administration (FDA) [10] for patients treated with rivaroxaban and apixaban when reversal of anticoagulation is needed for life-threatening bleeding [11].
A Rare Case of Spontaneous Cardiac Tamponade Induced by Concomitant Use of Rivaroxaban and Amiodarone
Factor Xa Inhibitor Prevents Recurrent Blood (lots Better than Aspirin.
Cardiovascular medicine
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