The Focal adhesion and
Gap junction pathways receive and send signals that affect the motility proliferation, differentiation, metabolic transport, apoptosis, and tissue homeostasis of ovarian follicle and mammary gland cells [21].
This study shows how quickly some important cell behaviors are mediated by
gap junction communication.
Normal distribution of atrionatriuretic factor (ANF) granules, an intact intercalated disc with clear identification of fully formed fascia adherence and desmosomes with a reconstruction of
gap junction (nexus) were also noticed.
Since the correction was not achieved when hAMSCs were cultured separately from CFBE41o- (CFBE) cells, we hypothesised that
gap junction (GJ) intercellular communication (GJIC) is likely to have a role in the rescue of basic defects in the CF airway epithelium.
According to previous studies, it is well known that the two kinds of vascular endothelial cell-cell junction, TJs and AJs, play key roles in the barrier function of BBB [2, 11]; nevertheless, very recently, researchers discovered a third category,
gap junction (GC) channels, and the cross work with other cell-cell junctions in maintaining the barrier function [12].
Regulation of
gap junction channels by infectious agents and inflammation in the CNS.
An example of the concept is ES1: Here the main question is whether a new AOP for developmental toxicity can be defined on the basis of
gap junction changes induced by toxicants, and whether such a key event (KE) would be beneficial for a KE-based test battery.
However, with their topography and discovery being lumped with the
gap junction field (i.e., connexin), they were thought for a long time to be more similar to connexin-based proteins.