The outcomes achieved by the scientists suggest that the therapeutic window for local
gene transfer in patients with DFNB9 congenital deafness could be wider than thought, and offers hope of extending these findings to other forms of deafness.
For many, the concept of horizontal
gene transfer may be new, but he explains it clearly and in a "breezy, conversational style" (Nature) that makes the pages turn quickly.
Biopharmaceutical company Renova Therapeutics disclosed on Thursday the receipt of the US Food and Drug Administration's (FDA) Fast Track designation for the its RT-100 AC6
gene transfer (Ad5.hAC6) lead product candidate for the treatment of heart failure with reduced ejection fraction (HFrEF).
He studies symbiosis and parasitism at the University of Victoria in Canada and says that far-flung
gene transfers provide genetic variation that fuels evolutionary processes.
Nevertheless,
gene transfer continues to be a highly promising approach to treating diseases of the heart and other organ systems.
The most established method for
gene transfer in fish is microinjection.
coli strain J53 was used as a recipient for the assessment of
gene transfer frequency.
In the study, the researchers administered stem cell factor (SCF) by
gene transfer shortly after inducing heart attacks in preclinical models directly into damaged heart tissue to test its regenerative repair response.
Reineke developed a
gene transfer vector based on synthetic polymers with an efficiency comparable to a viral vector, without the potential for life-threatening immune responses.
Among specific topics are electroporation gene therapy, selectively replicating Herpes simplex viral vectors, dendritic cell vaccination, RNA interference therapeutics for tumor therapy, and ethics in translational
gene transfer research.
Two issues of interest to consumers are the possibility of allergic reactions and horizontal
gene transfer, Giannopoulos says.
The study, "Safety Study of a Dual Anti-HTV
Gene Transfer Construct to Treat HIV-1 Infection," uses a gene medicine called Cal-1, developed in the lab of Nobel Laureate Dr.