Glycan heterogeneity by HILI-UPLC of Infinitam (c) and the reference product (a, b, d).
For a long time structure analysis of the
glycan moieties made only a rather slow progress, due to limitations of the used analytical methods.
With the intention of optimize the glycoproteins synthesis process, which was hindered by the limitations from homogeneous
glycans obtaining, production of the protein backbone, and linkage between
glycan and protein backbone, scientists in Creative Biolabs summarize existing knowledge and technologies to propose enhanced glycoprotein synthesis approaches such as native chemical ligation, bacterial oligosaccharyltransferase, glycoprotein remodeling, and in vivo suppressor tRNA technology.
'By supporting the work of leading researchers like Professor An, Agilent is contributing to advance the fields of
glycan analysis, biopharmaceutical characterization, and quality control,' stated executive sponsor of the award Kevin Killeen, Ph.D., Business Transition Manager for Agilent-ProZyme.
Transferrin and its
glycan isoform in cerebrospinal fluid (CSF)
The study enrolled 47 subjects, who were administered a high-protein diet and randomized to receive either KB195, a comparator
glycan, or negative control, and the dose was escalated during the study.
A research team from the University of Adelaide and Griffith University have been studying the interactions between the toxin and an abnormal
glycan (sugar) expressed on the surface of human cancer cells and released into the blood.
Trainees will have access to leading-edge
glycan research technologies at each of the participating institutions.
(NYSE: A) has closed the acquisition of privately-held
glycan analysis reagents, kits and standards provider ProZyme, Inc., the company said.