Therapeutic glycoprotein containing oligosaccharide chains (
glycans) covalently attached to amino acid side-chains plays a significant role in modulating yield, bioactivity, solubility, stability against proteolysis, immunogenicity, and clearance rate from circulation.
For the imprinting process, the researchers use a special method (boronate affinity controllable oriented surface imprinting) that is particularly controllable and makes it possible to imprint using chains of sugar building blocks (
glycans) as templates.
Although Tf
glycans influence physicochemical properties such as the hydration volume and exposure of hydrophobic patches, they did not affect any of the functions we examined.
Mounting evidence suggests
glycans play an important role in human development, health and disease, and should be taken into account when new therapeutics are designed and tested, the company added.
Founded in 1990, ProZyme is an industry leading developer and manufacturer of
glycan reagents, kits and standards, which are required for efficient sample prep in the analysis of free
glycans.
Among their topics are high-throughput screenings: new breeze in anti-Trypanosoma cruzi drug discovery, protein glycosylation in Trypanosoma cruzi and strategies based on mass spectrometry for characterizing
glycans and glycoproteins, omics approaches for understanding gene expression in Leishmania: clues for tackling Leishmaniasis, Entamoeba histolytica: from high-throughput technology to new drugs, and gene silencing and therapeutic targets against Acanthamoeba infections.
He joined NIBRT - The National Institute for Bioprocessing Research and Training, in 2007 based at the UCD Conway Institute of Biomolecular and Biomedical Research, representing NIBRT in the EU FP6 GLYFDIS - "
Glycans in Bodily Fluids, Potential for Disease Diagnostics" Consortium.
"A force from the Anbar Operations Command detonated (63) explosive devices in the form of
Glycans filled with (C4), which were planted by Daesh gangs in the 10th Division Division sector, where they were present, as this area contains a large number of IEDs," a statement by the operations command said.
Prostate cancer cells are surrounded by groups of sugars called
glycans, and previous studies have suggested that removing these sugars could help kill cancer cells.
The new, highly sensitive Luminex Multiplex
Glycan Array enables the kind of volume needed to establish associations between antibody levels in our blood to these complex sugars, or
glycans, and conditions from cancer to autoimmune disease and dementia, according to the new research.