The
HLA type is a biological system to distinguish between self and non-self.
In brief, by having a detailed list of unacceptable and acceptable donor antigens (based on the recipient's HLA antibody profile) and the high-resolution
HLA type of potential donors, an electronic crossmatch (paper crossmatch or crossmatch in silico) can be performed, perhaps one day obviating the need for a physical crossmatch.
In addition, Affymetrix Axiom HLA Analysis software enables affordable, high-throughput, accurate analysis of 11 classical loci at 4-digit resolution by imputing
HLA type from Axiom array-generated genotype data.
The three peaks shown in the electropherogram resulted from the cells of the most recent stem cell donor, the father, (
HLA type DPB1*04:01, 17:01) and from the patient, including the leukemic cells (
HLA type DPB1*04:01, 04:01).
(6) This technique is a solid-phase assay in which purified HLA molecules (either of a single
HLA type or a combination of types) are attached to beads.
The
HLA type for the patient R.Z., by the LABTYPE SSO Typing test (Luminex one Lambda Inc technology), showed these results: HLA A 01, A 29, B 18, B 51, DQB1 01, DQB1 05 , DRB1 11, DRB1 15 ...
A bone marrow donor's
HLA type must be a pretty exact match with a particular patient's
HLA type in order for transplantation to proceed.
The less specific
HLA type DR4 is seen in 82%-96% of patients with actinic prurigo and in 30%-40% of people who do not have the disorder.
To find someone's
HLA type is to determine which alleles she has at specific locations on the chromosome.
Further testing may indicate that your precise
HLA type is compatible with the patient.