T-cell lymphomas with a follicular helper phenotype, including follicular T-cell lymphoma and primary cutaneous follicular
helper T-cell lymphoma, may mimic PCFCL.
Over the 30 days of CS treatment, flow cytometry was used to detect the frequency of
helper T-cell (Th) subsets, Th1 and Th17, and CD4[sup]+ CD25[sup]+ regulatory T cells in the spleen and lymph nodes.
Missiaglia et al., "Integrative clinicopathological and molecular analyses of angioimmunoblastic T-cell lymphoma and other nodal lymphomas of follicular
helper T-cell origin," Haematologica, vol.
* Progesterone presence, which may suppress the maternal immune response and alter the balance between type-1
helper T-cell response and type-2
helper T-cell response.
Treatment with pioglitazone changes the
helper T-cell balance from Th1 to Th2 in the myocardium of rats with autoimmune myocarditis by upregulating the mRNA of Th2 cytokine IL-4 and by reducing the mRNA level of Th1 cytokine IFN-[gamma] [18].
Potential benefits include the control of acute retroviral symptoms, prevention of abnormal
helper T-cell function and reduction in the pace of decline, delaying or preventing decreased immune function and vulnerability to opportunistic infections, decreasing the initial viral load set point, which may decrease transmission, limiting viral evolution and diversity, potential slowing of the rate of disease progression among patients with a genetic predisposition, and decrease in the size of the latent HIV pool.
Several vaccination strategies have been evaluated in mouse and ferret models, including M2-expressing recombinant viruses, M2 recombinant proteins (20,21), M2-encoding plasmid DNA (29), and synthetic M2e peptides that were chemically linked to carrier proteins or synthetically linked to defined
helper T-cell determinants (22-24).
Antigen Express scientists have pioneered strategies for enhancing
helper T-cell responses to DNA vaccines by controlling the function of the immunoregulatory Ii-protein.
Defining promiscuous MHC class II
helper T-cell epitopes for the HER2/neu tumor antigen.
When the virus enters the body, it ravenously attacks an immune-system cell--a white blood cell called a
helper T-cell (see "The Life Cycle of HIV").
What we're spending substantial effort on right now is trying to formulate it in order to induce immune responses to all areas of the immune system, meaning
helper T-cell responses, cytotoxic T-cell responses, and antibody responses, and also eliciting consistent and high-level responses in the majority of patients.
HIV propagates by attacking a kind of immune cell known as a
helper T-cell. The researchers chose three patients and isolated from their bodies another type of white blood cell, the killer T-cell, which destroys HIV.