The enhancer region generally showed a different enrichment pattern for histone modifications than around the CTCFbs, suggesting that a local region of
heterochromatin is formed close to the expanded CTG-repeat, within a euchromatin region.
Between 14 and 76% of the tumor cells stained positive for
heterochromatin protein (HP1[gamma]) (Table 1 and Figure 1).
Trimethylated H3K9 (H3K9me3) is a posttranslational modification, and is commonly linked with both facultative and constitutive
heterochromatin formation as well as transcriptional repression (6).
C-band results showed that all constitutive
heterochromatin was confined to the X chromosome, differing from the pattern observed in Cavia and Galea.
The research findings described in this media release can be found in the 14 October online issue of Cancer Cell, under the title, "Wip1 controls global
heterochromatin silencing via ATM/BRCA1-dependent DNA methylation" by Doria Filipponi(1), Julius Muller(1), Alexander Emelyanov(1) and Dmitry V.
Loss of the Suv39h histone methyltransferases impairs mammalian
heterochromatin and genome stability.
On the other hand, histone H3K9 methylation is related to gene silencing and
heterochromatin formation.
Multiple spatially distincts types of facultative
heterochromatin on the human inactive X chromosome.
Distribution of C-band
heterochromatin in metaphase chromosomes of the silver crap, Hypophthalmichthys molitrix (Gyprinidae, Pisces).
In EMN method, electric field exposure induced an increase in electrophoretic mobility of cell nuclei (EMN index), decreased numbers of
heterochromatin granules near the inner membrane of cell nucleus, and induced cell membrane damage; but cell viability was conserved.
In many cases, transgenes are rapidly inactivated (silenced), probably by the influence of the neighboring
heterochromatin that makes them inaccessible to transcriptional machinery (24), (25).
Finally, emerging evidence indicates that some mature miRNAs are transported back to the nucleus, where they mediate the formation of
heterochromatin (3) (Gonzalez et al.