Scientists at Sahlgrenska Academy, University of Gothenburg, Sweden, showed that the gut microbiota of people with treatment-naEaive type 2 diabetes can be linked to a different metabolism of the amino acid histidine, which is mainly derived from the diet.
The study explored that the gut microbiota of people with treatment-naive Type-2 diabetes can be linked to a different metabolism of the amino acid histidine, which is mainly derived from the diet.
In general, it was shown that these complexes bind to the heteroatom in the side chain of methionine [18-25] or histidine [19,20,26-34] and promote cleavage of the amide bond involving the carboxylic group of the anchoring amino acid.
Screening the DNA of 370 schizophrenia patients, they found a single missense mutation, R292H, that changed the amino acid of this protein from arginine to histidine in two patients.
Many different proteins are involved in HCCa including insulin growth factor (IGF) II, signal transducers and activators of transcription (STAT) 3, STAT4, mothers against decapentaplegic homolog 4 (SMAD 4), fragile histidine triad (FHIT) and selective internal radiation therapy (SIRT) etc.
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