In addition, there can be no assurance as to timing or success of the Phase 3 clinical trial of SGX942 (dusquetide) as a treatment for oral mucositis in patients with head and neck cancer receiving chemoradiation therapy or the Phase 3 clinical trial of SGX301 (synthetic
hypericin) for the treatment of cutaneous T-cell lymphoma.
The second product noted earlier is the Phase 3 FLASH (Fluorescent Light Activated Synthetic
Hypericin) trial, which is testing SGX301 in patients with CTCL.
The flowers and leaves of SJW contain bioactive ingredients hyperforin and
hypericin that may affect neurotransmitters in the body.
The activity of the main chemical constituent,
hypericin, inhibits certain enzymes in the brain and helps maintain normal mood patterns.
In 1951, it was determined that the prominent active substance is
hypericin (4).
Soligenix announced it has received a recommendation from the independent data monitoring committee, or DMC, to continue enrolling into the company's Phase 3 Fluorescent Light Activated Synthetic
Hypericin, or FLASH, study for SGX301 in the treatment of cutaneous T-cell lymphoma, or CTCL.
John's Wort has been standardized by several brand and have a chemical composition of 0.3% of
hypericin and 3-5% hyperforin, these chemicals are present naturally in the St.
There are also arguments claiming that Hypericum perforatum or its' bioactive component,
hypericin, may be useful in the treatment of various types of cancer (10).
Flavonoid, tannin and
hypericin concentrations in the leaves of St.
These are naphthodianthrones (
hypericin, pseudohypercin), phloroglucinols (hyperforin, adipherforin), flavonoids (rutin, hyperoside, quercitrin) xanthones and tannins.
They were given Hypericum perforatum capsules (900 mg a day and standardized to 0.18%
hypericin and 3.38% hyperiforin) or placebo.