[5] Granisetron is an
indazole derivative, which is a more selective 5HT3 antagonist than ondansetron.
The synthetic compound hypoxic+ 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl
indazole (YC-1) has superior anti-angiogenic and anti-tumor activities.
Guedes da Silva et al., "Tuning of redox potentials for the design of ruthenium anticancer drugs-an electrochemical study of [trans-RuCl4L (DM SO)]-and [trans-RuCl4L2]-complexes, where L = imidazole, 1,2,4-triazole,
indazole," Inorganic Chemistry, vol.
Doskocz et al., "On the interactions of
indazole derivative with nucleosides - toward modeling the cytotoxic activity mechanism," Computational and Theoretical Chemistry, vol.
2004) and produce a range of bioactive compounds including the indole derivative indazole-3-carbaldehyde (
Indazole) (Fotso Fondja Yao et al.
Derivatives of
indazole and other pyrazole-containing condensed systems are attracting attention because of their biological activity and the possibilities of further conversions.
Indazole derivatives are reported to exhibit antibacterial [1,2], antifungal [1.2], antiproliferative [3], antigiogenic [3], antiarrhythmic and analgesic [4] activities and antihypertensive properties [5], while quinazolines exhibit antitumor [6], antimicrobial [7] antitubercular [8], antiagonists [9], anticonvulsant [10] and analgesic[11] activities.
(iii) Soluble guanylyl cyclase GC-S (synthesizes cGMP) (NO independent activator YC-1 [3-(5'-hydroxymethy1-2'-fury1)-1-benzyl
indazole, 10 [micro]umo1 [1.sup.-1]]) (Lee et al., 2011)
Effects of NG-nitro-L-arginine methyl ester, 7-nitro
indazole, and agmatine on pentylenetetrazol-induced discriminative stimulus in Long-Evans rats Prog Neuropsychopharmacol Biol Psychiatry 2002; 26:567-73.
The effect of 7-nttro
indazole on pentobatbital-induced sleep in mice.